The propriety of the gynecological mass screening-Comparison of the liquid based method and the conventional method-

DOI 10 Citations 13 References

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  • 子宮頸がん検診標本の適否状況と発見病変―Ｌｉｑｕｉｄ　ｂａｓｅｄ　ｃｙｔｏｌｏｇｙ法とｃｏｎｖｅｎｔｉｏｎａｌ法の比較―
  • —Comparison of the liquid based method and the conventional method—
  • —Liquid based cytology 法と conventional 法の比較—

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Abstract

Objective : As a method of preparing specimens for cervical cancer screening, liquid-based cytology (LBC) and direct smears (conventional method) were compared in terms of whether specimens prepared by LBC and the conventional method are satisfactory or unsatisfactory for screening and the lesions detected, and the usefulness of LBC was thereby assessed.<br>Study Design : The subjects were 76,676 patients who underwent screening in Niigata Prefecture during the 2-year period from 2005 to 2006.<br>Methods : Judgment as to whether the specimens were satisfactory or unsatisfactory was made with reference to The Bethesda System (TBS) criteria (2001) and the partial TBS system for LBC (Cervix brush sampling in 43,857, cotton swab sampling in 2,896, spatula sampling in 2,521, and others in 758 patients) and the conventional method (cotton swab sampling in 464 and spatula sampling in 26,180 patients). The lesions detected on the initial examination (LBC in 11,596 and conventional method in 6,086 patients) and on re-examination (repeat LBC in 20,914, repeat conventional method in 20,562, and the conventional method followed by LBC in 17,518 patients) were assessed according to whether the subject had undergone a medical examination.<br>Results : The rate of unsatisfactory specimens by LBC was significantly lower than that by the conventional method (P<0.001). According to the sampling devices (cotton swab and spatula), the cell count and transformation zone cell frequency by LBC were significantly less than those by the conventional method (P<0.001). According to whether the subject had undergone a medical examination, the frequency of infiltrating cancer detected in the specimens by LBC on the initial examination was high. On re-examination, carcinoma in situ (CIS) and infiltrating cancer were detected in 3 and 2, respectively, of the patients who underwent repeat tests by the conventional method, while CIS and infiltrating cancer were detected in 1 and 0, respectively, of the patients who underwent repeat LBC.<br>Conclusion : LBC is excellent for preparing satisfactory specimens and for efficacious screening.

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