Development of stagnation mastitis animal model

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  • うっ滞性乳腺炎動物モデルの作成
  • ウッタイセイ ニュウセンエン ドウブツ モデル ノ サクセイ

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Abstract

Mastitis one of the disease attack mothers during the lactation period. Especially, it is assumed that stagnation mastitis is caused by lacteal discharge disorder, and conceivably, meals are the principal risk factor. Establishment of animal experiment method was tried to inspect efficiently meal components in association with the mastitis onset. At first, the mammary gland tissues were stained with hematoxylin and eosin after the pups were separated from the mother mouse during a lactation period for forced weaning. Inflammation such as epithelial cells shedding, humoral shift to interstitium and invasion of mononuclear cells to interstitium were confirmed after 96 hours from weaning. In addition, measuring the mast cell count in order to evaluate inflammatory degree indicated that the cell count increased significantly in mammary gland tissue of forced weaning mice in comparison with continued nursing mice. The stagnation mastitis induction model made by extremely easy operation of forced weaning will give an experimental tool to elucidate relation between mastitis and diets.

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