CONTROLS FOR MONITORING THE DETERIORATION OF STORED BLOOD SAMPLES IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY) Controls for monitoring the deterioration of stored blood samples in the Japan Multi-institutional Collaborative Cohort Study (J-MICC Study)

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Author(s)

    • NAITO M
    • Department of Preventive Medicine-Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine
    • Okada Rieko
    • Department of Preventive Medicine-Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine
    • Ishida Yoshiko
    • Department of Preventive Medicine-Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine
    • Nishio Kazuko
    • Department of Preventive Medicine-Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine
    • Hishida Asahi
    • Department of Preventive Medicine-Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine
    • Wakai Kenji
    • Department of Preventive Medicine-Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine
    • Hamajima Nobuyuki
    • Department of Preventive Medicine-Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine

Abstract

Cohort studies commonly store blood samples to measure the associations of biomarkers with disease risks for a long time after the study subjects are enrolled. To obtain valid measurements of the stored samples, monitoring their degree of deterioration is essential. The first stage of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study launched in 2005 included a project to validate the quality of stored blood samples. This project will compare the measurements of representative molecules over different storage periods (1, 4, and 8 years after sampling, and when a nested case-control study is conducted), different storage temperatures (–80 and –150°C), and different separation conditions (temperature and time) before storage. For these purposes, 28 ml of peripheral blood from 10 people was sampled four times annually, using two tubes for serum and two EDTA -Na tubes for plasma. These samples were treated using the process adopted for the J-MIC study protocol, and stored in tubes containing 300 μl of serum or plasma labeled with two-dimensional bar codes. The sampling was started in 2006, and some of the specimens will be stored until the end of the J-MICC Study in 2035. The resulting findings will produce valuable information on the stability of the molecules, not only for the J-MICC Study, but also for other cohort studies.

Journal

  • Nagoya Journal of Medical Science

    Nagoya Journal of Medical Science 70(3-4), 107-115, 2008-08

    Nagoya University School of Medicine

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