Effect of Collagen Oligopeptide Injection on Rabbit Tenositis Effect of Collagen Oligopeptide Injection on Rabbit Tenositis

Access this Article

Author(s)

    • WATANABE Takafumi
    • Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
    • NAGAYASU Aya
    • Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
    • HOSAKA Yoshinao
    • Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
    • KOKAI Yasuo
    • Department of Biomedical Engineering, School of Medicine, Sapporo Medical University
    • TAKEHANA Kazushige
    • Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University

Abstract

Effects of the collagen oligopeptide (COP) were examined by its repeat injection into the inflammatory rabbit Achilles tendon (<i>Tendo calcaneus communis</i>), in which tenositis was induced by injection of bacterial collagenase. COP was evaluated 5 times over a period of 3 weeks to 1 month after injection of collagenase. At 1 month after treatment, the therapeutic effect of COP was evaluated by examining the structure of collagen fibrils, amount and components of glycosaminoglycans (GAGs) and matrix metalloproteinases (MMPs), and compared with the saline injection, control, and normal groups. The Achilles tendon of rabbit in the control group (no COP injection) and saline injection group showed a notable increase in the number of fine collagen fibrils, a change in GAG composition and increase in the amount of pro-MMP-2, indicating the weakening of the tendon. In contrast, the size distribution of collagen fibrils, GAG composition and the amount of pro-MMP-2 was similar to those in the normal group. These results suggest that COP injection promotes healing processes of the tendon injury.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 70(12), 1295-1300, 2008-12-25

    Japanese Society of Veterinary Science

References:  39

Codes

  • NII Article ID (NAID)
    110007021707
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    09167250
  • NDL Article ID
    9760124
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • Data Source
    CJP  NDL  NII-ELS  IR  J-STAGE 
Page Top