Mice are Not Susceptible to Hepatitis E Virus Infection

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  • LI Tian-Cheng
    Department of Virology II, National Institute of Infectious Diseases
  • SUZAKI Yuriko
    Division of Experimental Animals Research, National Institute of Infectious Diseases
  • AMI Yasushi
    Division of Experimental Animals Research, National Institute of Infectious Diseases
  • TSUNEMITSU Hiroshi
    Research Team for Viral Diseases, National Institute of Animal Health
  • MIYAMURA Tatsuo
    Department of Virology II, National Institute of Infectious Diseases
  • TAKEDA Naokazu
    Department of Virology II, National Institute of Infectious Diseases

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  • Virology: Mice are not susceptible to hepatitis E virus infection

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Abstract

To determine whether or not mice are susceptible to hepatitis E virus (HEV) infection, C57BL/6 mice were experimentally infected with genotypes 1, 3 and 4 HEV by intravenous injection. Serum and stool samples were collected and used to detect HEV RNA and anti-HEV antibodies by RT-PCR and ELISA. The virus infection was monitored up to two months after inoculation; however, none of the serum or stool samples was positive for virus replication, demonstrating that C57BL/6 mice were not susceptible to HEV.<br>

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