Effectiveness of Nocturnal Home Oxygen Therapy to Improve Exercise Capacity, Cardiac Function and Cardiac Sympathetic Nerve Activity in Patients With Chronic Heart Failure and Central Sleep Apnea
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- Toyama Takuji
- Gunma Prefectural Cardiovascular Center
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- Seki Ryotaro
- Gunma Prefectural Cardiovascular Center
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- Kasama Shu
- Department of Cardiovascular Medicine, Gunma University School of Medicine
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- Isobe Naoki
- Gunma Prefectural Cardiovascular Center
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- Sakurai Shigeki
- Gunma Prefectural Cardiovascular Center
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- Adachi Hitoshi
- Gunma Prefectural Cardiovascular Center
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- Hoshizaki Hiroshi
- Gunma Prefectural Cardiovascular Center
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- Oshima Shigeru
- Gunma Prefectural Cardiovascular Center
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- Taniguchi Koichi
- Gunma Prefectural Cardiovascular Center
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Background Central sleep apnea, often found in patients with chronic heart failure (CHF), has a high risk of poor prognosis. Methods and Results This study involved 20 patients with CHF (left ventricular ejection fraction (LVEF) <45%, M/F =19/1, age 65±10 years) and an apnea-hypopnea index (AHI) >5 times/h who were divided into 2 groups: 10 patients treated with nocturnal home oxygen therapy (HOT) and 10 patients without HOT (non-HOT). All patients had dilated cardiomyopathy and underwent overnight polysomnography, cardiopulmonary exercise testing, and nuclear cardiac examinations to evaluate AHI, exercise capacity according to the specific activity scale and oxygen uptake at anaerobic threshold and peak exercise (peak VO2). Cardiac function according to 99mTc-MIBI QGS, and the total defect score (TDS), H/M ratio and the washout rate (WR) on 123I-metaiodobenzylguanidine (MIBG) imaging were calculated for all patients. As compared with the non-HOT group, the HOT group demonstrated a greater reduction in AHI (26.1±9.1 to 5.1±3.4), 123I-MIBG TDS (31±8 to 25±9), and 123I-MIBG WR (48±8% to 41±5%) and a greater increase in the specific activity scale (4.0±0.9 to 5.8±1.2 Mets), peak VO2 (16.0±3.8 to 18.3±4.7 ml · min-1 · kg-1), and LVEF (27±9% to 37±10%). Conclusions HOT improves exercise capacity, cardiac function, and cardiac sympathetic nerve activity in patients with CHF and central sleep apnea. (Circ J 2009; 73: 299 - 304)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 73 (2), 299-304, 2009
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680081883008
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- NII論文ID
- 110007042178
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 使用不可