Role of Heart-type Fatty Acid Binding Protein in the Brain Function

• MOTOHASHI Keiju

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University

• YAMAMOTO Yui

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University

• SHIODA Norifumi

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University

• KONDO Hisatake

  Department of Histology, Graduate School of Medicine, Tohoku University

• OWADA Yuji

  Department of Organ Anatomy, Graduate School of Medicine, Yamaguchi University

• FUKUNAGA Kohji

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University Thohoku University 21st Century COE Program “CRESCENDO”

Bibliographic Information

Other Title

• 高次脳機能における心臓型脂肪酸結合タンパク質の役割
• コウジ ノウ キノウ ニ オケル シンゾウガタ シボウサン ケツゴウ タンパクシツ ノ ヤクワリ

Abstract

  Long-chain polyunsaturated fatty acids (LCPUFAs) are components of membrane phospholipids and they are abundant in the brain. LCPUFAs are supposed to be involved in several brain functions including emotion, learning and memory. However, the mechanisms of effects of LCPUFAs on brain functions at cellular and molecular levels remains unclear. Because LCPUFAs are insoluble in the intracellular compartment, specific transporters are required to deliver LCPUFAs for appropriate intracellular compartments. Fatty acid binding proteins (FABPs) are believed to play crucial roles as their cellular shuttles. Among various FABPs, heart-type fatty acid binding protein (H-FABP) is highly expressed in neurons of the mature brain and involved in arachidonic acid incorporation in the brain. Moreover, the association of H-FABP and dopamine D2L receptor has been documented by our studies. In this context, we here examined behavioral and molecular biological phenotype of H-FABP gene-ablated mice to clarify function of H-FABP in the higher brain functions.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 129 (2), 191-195, 2009-02-01

  The Pharmaceutical Society of Japan

Keywords

• fatty acid-binding protein
• dopamine receptor
• CaM kinase II
• polyunsaturated fatty acids
• cAMP-responsive element binding protein (CREB)

Details

• CRID: 1390001206129191424
• NII Article ID: 110007046096
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.129.191
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 10160663
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10160663
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/129/2/129_2_191/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009116855
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed