Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems

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Author(s)

    • Takeda Ken TAKEDA Ken
    • Department of Hygiene Chemistry, Faculty of Pharmaceutical Science, Faculty of Science and Technology, Tokyo University of Science
    • KUBO IRIE Miyoko
    • Department of Hygiene Chemistry, Faculty of Pharmaceutical Science, Faculty of Science and Technology, Tokyo University of Science
    • FUJIMOTO Rie
    • Department of Hygiene Chemistry, Faculty of Pharmaceutical Science, Faculty of Science and Technology, Tokyo University of Science
    • TABATA Masako
    • Department of Hygiene Chemistry, Faculty of Pharmaceutical Science, Faculty of Science and Technology, Tokyo University of Science
    • OSHIO Shigeru
    • Department of Hygiene Chemistry, Ohu University School of Pharmaceutical Sciences
    • NIHEI Yoshimasa
    • Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
    • IHARA Tomomi
    • Department of Pathology, Tochigi Institute of Clinical Pathology
    • SUGAMATA Masao
    • Department of Pathology, Tochigi Institute of Clinical Pathology

Abstract

Nanomaterials are being used increasingly for commercial purposes, yet little is known about the potential health hazards such materials may pose to consumers and workers. Here we show that nano-sized titanium dioxide (TiO<sub>2</sub>), which is used widely as a photo-catalyst and in consumer products, administered subcutaneously to pregnant mice is transferred to the offspring and affects the genital and cranial nerve systems of the male offspring. Nanoparticles identified as TiO<sub>2</sub> by energy-dispersive X-ray spectroscopy were found in testis and brain of exposed 6-week-old male mice. In the offspring of TiO<sub>2</sub>-injected mice, various functional and pathologic disorders, such as reduced daily sperm production and numerous caspase-3 (a biomarker of apoptosis) positive cells in the olfactory bulb of the brain, were observed. Our findings suggest the need for great caution to handle the nanomaterials for workers and consumers.

Journal

  • Journal of Health Science

    Journal of Health Science 55(1), 95-102, 2009-02-01

    The Pharmaceutical Society of Japan

References:  31

Cited by:  7

Codes

  • NII Article ID (NAID)
    110007055924
  • NII NACSIS-CAT ID (NCID)
    AA11316464
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13449702
  • NDL Article ID
    9782153
  • NDL Source Classification
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL Call No.
    Z54-J464
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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