磁気共鳴法を用いた生体レドックス画像化  [in Japanese] Analysis of In vivo Redox Status with Magnetic Resonance Technique  [in Japanese]

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Author(s)

    • 市川 和洋 ICHIKAWA Kazuhiro
    • 九州大学大学院薬学研究院機能分子解析学分野 Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University
    • 山田 健一 YAMADA Ken-ichi
    • 九州大学大学院薬学研究院機能分子解析学分野 Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University
    • 安川 圭司 [他] YASUKAWA Keiji
    • 九州大学大学院薬学研究院機能分子解析学分野 Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University
    • 内海 英雄 UTSUMI Hideo
    • 九州大学大学院薬学研究院機能分子解析学分野 Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University

Abstract

  <i>In vivo</i> redox reaction is involved in processes of oxidative diseases. The redox imaging technique is important to diagnose redox-induced diseases and to assess cure effects of pharmaceutical drugs. A group of nitroxyl radicals is sensitive to redox reactions and we have investigated mechanisms of oxidative diseases, including diabetes, ischemia reperfusion injuries and gastric ulcer. ESR technique has been utilized in analysis of free radicals, which is generated through imbalance of <i>in vivo</i> redox status. We have been developing magnetic resonance approaches for imaging free radicals/redox status in living animals. Overhauser enhanced MRI (OMRI) is a new technique for imaging <i>in vivo</i> redox status in animals via Overhauser effect. We have developed nanometer-scale imaging and simultaneous assessment of redox processes by using OMRI with <sup>14</sup>N- and <sup>15</sup>N- labeled nitroxyl probes with different distribution properties. We also developed a home-built OMRI imager based on an electromagnet for L-band ESRI. This OMRI technique with dual probes may become a powerful tool to clarify mechanisms of disease and to monitor pharmaceutical therapy.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 129(3), 273-278, 2009-03-01

    The Pharmaceutical Society of Japan

References:  32

Codes

  • NII Article ID (NAID)
    110007123177
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    00316903
  • NDL Article ID
    10193598
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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