Analysis of <i>In vivo</i> Redox Status with Magnetic Resonance Technique

• ICHIKAWA Kazuhiro

  Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University

• YAMADA Ken-ichi

  Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University

• YASUKAWA Keiji

  Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University

• UTSUMI Hideo

  Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University

Bibliographic Information

Other Title

• 磁気共鳴法を用いた生体レドックス画像化
• ジキ キョウメイホウ オ モチイタ セイタイ レドックス ガゾウカ

Abstract

  In vivo redox reaction is involved in processes of oxidative diseases. The redox imaging technique is important to diagnose redox-induced diseases and to assess cure effects of pharmaceutical drugs. A group of nitroxyl radicals is sensitive to redox reactions and we have investigated mechanisms of oxidative diseases, including diabetes, ischemia reperfusion injuries and gastric ulcer. ESR technique has been utilized in analysis of free radicals, which is generated through imbalance of in vivo redox status. We have been developing magnetic resonance approaches for imaging free radicals/redox status in living animals. Overhauser enhanced MRI (OMRI) is a new technique for imaging in vivo redox status in animals via Overhauser effect. We have developed nanometer-scale imaging and simultaneous assessment of redox processes by using OMRI with ¹⁴N- and ¹⁵N- labeled nitroxyl probes with different distribution properties. We also developed a home-built OMRI imager based on an electromagnet for L-band ESRI. This OMRI technique with dual probes may become a powerful tool to clarify mechanisms of disease and to monitor pharmaceutical therapy.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 129 (3), 273-278, 2009-03-01

  The Pharmaceutical Society of Japan

Keywords

• <i>in vivo</i> redox status
• imaging modality
• electron spin resonance
• nitroxyl radical
• overhauser enhanced magnetic resonance imaging (OMRI)

Details

• CRID: 1390282681103692032
• NII Article ID: 110007123177
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.129.273
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 10193598
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10193598
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/129/3/129_3_273/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009188991
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed