Asymptomatic Cerebral Microbleeds Seen in Healthy Subjects Have a Strong Association With Asymptomatic Lacunar Infarction

DOI Web Site 被引用文献9件 参考文献33件
  • Igase Michiya
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine Anti-Aging Center, Ehime University Hospital
  • Tabara Yasuharu
    Department of Fundamental Medical Science, Ehime University Graduate School of Medicine Anti-Aging Center, Ehime University Hospital
  • Igase Keiji
    Department of Neurosurgery, Washokai Sadamoto Hospital
  • Nagai Tokihisa
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine
  • Ochi Namiko
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine Anti-Aging Center, Ehime University Hospital
  • Kido Tomoko
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine Anti-Aging Center, Ehime University Hospital
  • Nakura Jun
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine
  • Sadamoto Kazuhiko
    Department of Neurosurgery, Washokai Sadamoto Hospital
  • Kohara Katsuhiko
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine
  • Miki Tetsuro
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine Anti-Aging Center, Ehime University Hospital

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Background: Cerebral microbleed (CMB), which is conspicuous on gradient-echo T2*-weighted magnetic resonance imaging, is a risk factor of intracerebral hemorrhage (ICH). CMBs have been detected even in neurologically healthy persons, who also seem prone to be affected by stroke, not only ICH but also cerebral infarction. Methods and Results: The presence of CMB was investigated in brain dock participants, making reference to silent lacunar infarction (SLI). Participants comprised 377 neurologically healthy persons and 21 (5.6%) had CMB detected, which was associated with a high incidence of hypertension, other conventional risk factors having no significant correlation with CMB. In a simple correlation analysis, CMB showed a positive association with age and systolic blood pressure (SBP). Logistic regression analysis revealed that SLI was the factor most strongly associated with CMB. Moreover, individuals who had both CMB and SLI had higher SBP than other groups. Conclusions: The etiology of CMB is similar to that of SLI. (Circ J 2009; 73: 530 - 533)<br>

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  • Circulation Journal

    Circulation Journal 73 (3), 530-533, 2009

    一般社団法人 日本循環器学会

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