Relationship Between Thin Cap Fibroatheroma Identified by Virtual Histology and Angioscopic Yellow Plaque in Quantitative Analysis With Colorimetry
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- Yamamoto Masanori
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Takano Masamichi
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Okamatsu Kentaro
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Murakami Daisuke
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Inami Shigenobu
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Xie Yong
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Seimiya Koji
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Ohba Takayoshi
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Seino Yoshihiko
- Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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- Mizuno Kyoichi
- Division of Cardiology, Nippon Medical School
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Background: Thin cap fibroatheroma (TCFA) is considered to be a vulnerable plaque. Virtual Histology-intravascular ultrasound (VH-IVUS) can precisely identify TCFA in vivo. Intense yellow plaque on angioscopy determined by quantitative colorimetry with L*a*b* color space corresponds with histological TCFA; in particular, a plaque of color b* value >23 indicates an atheroma with a fibrous cap thickness <100 μm. In the present study, the relationship between VH-TCFA and angioscopic plaque color determined by colorimetry was investigated. Methods and Results: Fifty-seven culprit plaques in 57 patients were evaluated by VH-IVUS and angioscopy. VH-TCFA was defined as a plaque with a necrotic core >10% of plaque area without overlying fibrous tissue, and angioscopic TCFA was a plaque with b* value >23. The frequency of angioscopic TCFA was higher in the VH-TCFA group than in the VH-non-TCFA group (74% vs 23%, P=0.0002). Moreover, yellow color intensity (b* value) significantly correlated with plaque classification on VH-IVUS. When TCFA detected with angioscopy was used as the gold standard, the sensitivity, specificity, and accuracy for TCFA with VH-IVUS was 68%, 81%, and 75%, respectively. Conclusions: VH-TCFA strongly correlated with angioscopic TCFA determined by a quantitative analysis with colorimetry. (Circ J 2009; 73: 497 - 502)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 73 (3), 497-502, 2009
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205102918912
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- NII論文ID
- 110007126729
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 使用不可