Induction of osteoprotegerin mRNA during differentiation of monocytes into macrophages

• Notohara Yasuhiro

  Graduate School of Dentistry (Periodontology), Osaka Dental University

• Nagano Yutaka

  Department of Internal Medicine, Osaka Dental University

• Domae Naochika

  Department of Internal Medicine, Osaka Dental University

• Ueda Masatoshi

  Department of Periodontology, Osaka Dental University

抄録

We investigated the mRNA expression of osteoprotegerin, receptor activator of nuclear factor-_κB (RANK) and RANK ligand (RANKL) in human leukemia cell lines. When the cells took on a macrophage-like morphology after treatment with a phorbol ester, mRNA for osteoprotegerin was clearly induced. In contrast, RANK or RANKL mRNA expression did not change significantly.<br> Considering that monocytic leukocytes are often found in periodontitis and osteoprotegerin inhibits maturation of osteoclast precursor cells into osteoclasts, our data suggest that differentiation of monocytes into macrophages in periodontitis may prevent local osteoclastogenesis. This could be a defensive mechanism against bone resorption during the course of periodontitis.

収録刊行物

• Journal of Osaka Dental University

  Journal of Osaka Dental University 43 (1), 37-42, 2009

  大阪歯科学会

キーワード

• Osteoprotegerin
• Osteoclast
• Macrophage
• RANK
• RANKL

詳細情報

• CRID: 1390001204961442560
• NII論文ID: 110007160621
• NII書誌ID: AA00704144
• DOI: 10.18905/jodu.43.1_37
• ISSN: 21896488
• ISSN: 04752058
• Web Site: https://search.jamas.or.jp/link/ui/2009307646
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可