Inhibitory Effects of Osemozotan, a Serotonin 1A-Receptor Agonist, on Methamphetamine-Induced c-Fos Expression in Prefrontal Cortical Neurons

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  • Tsuchida Rie
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Kubo Masahiro
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Shintani Norihito
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Abe Michikazu
    Pharmacology Department IV, Mitsubishi Tanabe Pharma Co.
  • Köves Katalin
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University
  • Uetsuki Kazuki
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Kuroda Mariko
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Hashimoto Hitoshi
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University Center for Child Mental Development, Graduate School of Medicine, Osaka Univeersity
  • Baba Akemichi
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University

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Psychostimulants induce hyperlocomotion in normal subjects, although, they are effective in producing a calming effect in hyperactive subjects. This paradoxical effect has been related to changes in serotonin (5-HT) neurotransmission in hyperactive dopamine transporter-knockout mice. In addition, we observed that hyperlocomotion in mice lacking pituitary adenylate cyclase-activating polypeptide was attenuated by amphetamine dependent on 5-HT1A receptor signaling and that amphetamine, when co-administered with a 5-HT1A agonist, produced a calming effect in wild-type mice. Here, in an attempt to address how 5-HT1A receptor signaling exerts the calming action of psychostimulants, we examined c-Fos expression in several brain regions after administration of methamphetamine and osemozotan, a selective 5-HT1A receptor agonist. The number of c-Fos-positive cells was increased in the medial prefrontal cortex, striatum and nucleus accumbens in methamphetamine (3 mg/kg body weight)-injected mice. Osemozotan (1 mg/kg) significantly reduced the methamphetamine-induced c-Fos expression in the medial prefrontal cortex and striatum, but not in the nucleus accumbens. This osemozotan action was completely blocked by the 5-HT1A receptor antagonist WAY-100635 (1 mg/kg). As the prefrontal cortex is considered to be involved in the beneficial actions of psychostimulant medications for attention-deficit/hyperactivity disorder, the present result showing 5-HT1A-mediated inhibition of corticostriatal activity may partly be related to this psychostimulant action.

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