ビスホスホネート系薬剤関連顎骨壊死の現状と対策 A perspective on bisphosphonate-related osteonecrosis of the jaw

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著者

    • 池邉 哲郎 IKEBE Tetsuro
    • 福岡歯科大学 口腔・顎顔面外科学講座 口腔外科学分野 Section of Oral Surgery, Department of Oral and Maxillofacial Surgery, Fukuoka Dental College
    • 大関 悟 OZEKI Satoru
    • 福岡歯科大学 口腔・顎顔面外科学講座 口腔腫瘍学分野 Section of Oral Oncology, Department of Oral and Maxillofacial Surgery, Fukuoka Dental College

抄録

An increasing number of cases for bisphosphonate-related osteonecrosis of the jaw (BRONJ) have been reported since the first publication regarding it in 2003. Bisphosphonate, a drug to inhibit osteoclast activity, is administered intravenously or orally to the patients suffering from multiple myeloma, cancer bone metastasis and osteoporosis in order to treat the pathological bone resorption. In BRONJ, however, this drug is thought to impair bone turnover and angiogenesis of the jaw, leading to bone necrosis as an adverse side effect. Bone necrosis is occasionally triggered by dental surgery such as tooth extraction, promoted by bacterial infection, and exposed out of gingiva. The incidence of BRONJ in the patients taking oral bisphosphonate is very rare, but there have been considerable numbers of BRONJ occurring. Because the population of osteoporosis patients taking oral bisphosphonate increases year after year, dentists and oral surgeons must be careful at treating such patients for BRONJ. In this review, the recent findings, concepts and management for BRONJ are presented. The occurrence of BRONJ seems to clarify the critical role, osteoclasts play in the bioregulation mechanism of the jaw.

収録刊行物

  • 福岡歯科大学学会雑誌

    福岡歯科大学学会雑誌 35(1), 1-10, 2009-03-31

    福岡歯科大学学会

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各種コード

  • NII論文ID(NAID)
    110007161747
  • NII書誌ID(NCID)
    AN00216288
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    03850064
  • データ提供元
    CJP書誌  NII-ELS 
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