Elevated BNP is a useful predictor of cardiac dysfunction during treatment of _<98>A_3 protocol in two patients with stage 4 neuroblastoma

NDL Digital Collections 9 References
  • ENOMOTO,Yuki
    Department of Pediatrics Tsukuba University Hospital
  • FUKUSHIMA,Takashi
    Department of Pediatrics Tsukuba University Hospital:Graduate school of Comprehensive Human Sciences, University of Tsukuba
  • NAKAO,Tomohei
    Department of Pediatrics Tsukuba University Hospital
  • MIYATA,Daiki
    Department of Pediatrics Tsukuba University Hospital
  • NISHIMURA,Yoko
    Department of Pediatrics Tsukuba University Hospital
  • OKAMOTO,Miho
    Department of Pediatrics Tsukuba University Hospital
  • TAKAHASHI,Miho
    Department of Pediatrics Tsukuba University Hospital:Graduate school of Comprehensive Human Sciences, University of Tsukuba
  • SHIMIZU,Takashi
    Department of Pediatrics Tsukuba University Hospital:Graduate school of Comprehensive Human Sciences, University of Tsukuba
  • HIRAI,Misako
    Department of Pediatric Surgery Tsukuba University Hospital:Graduate school of Comprehensive Human Sciences, University of Tsukuba
  • KANEKO,Michio
    Department of Pediatric Surgery Tsukuba University Hospital:Graduate school of Comprehensive Human Sciences, University of Tsukuba
  • MATSUI,Akira
    Department of Pediatrics Tsukuba University Hospital:Graduate school of Comprehensive Human Sciences, University of Tsukuba

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  • BNPが多剤併用化学療法における心筋毒性の評価に有用であった2幼児例

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Abstract

_<98>A_3プロトコールを遂行する上で心毒性は大きな制約条件となりえる.BNPは心不全のマーカーとしてだけでなく心毒性の早期評価にも有効である.我々が経験した2例において,進行神経芽腫に対する_<98>A_3プロトコールの遂行には,心筋毒性の早期評価が重要であり,心電図・心エコー検査に加えてBNPの定期的な測定と,小児循環器専門家との密接な共同診療が必須であった.

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