JPLTのプロトコールに従って術前化学療法を施行した新生児肝芽腫の1例 [in Japanese] A case of neonatal hepatoblastoma treated by JPLT protocol [in Japanese]
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A one-month-old boy with hepatoblastoma was treated according to the protocol of the Japanese Study Group for Pediatric Liver Tumor (JPLT). Serum alpha-fetoprotein was markedly elevated and the tumor occupied the most of the medial segment of the left lobe and part of the right lobe (PRETEXT III), therefore pre-operative chemotherapy was started. The anti-cancer agents were reduced to 30% of the standard adult dosage, because the toxicity is more increased in neonates and infants than in older children. After two courses of chemotherapy, the tumor size was decreased and complete tumor resection was safely performed. Two more courses of chemotherapy were added. Serum alpha-fetoprotein was decreased but was not in the normal range. However AFP-L3 was normalized and no tumor was detected by CT scan, therefore we terminated the treatment. The patient has been alive without the tumor for 2 years.
- 小児がん : 小児悪性腫瘍研究会記録 = Pediatric oncology
小児がん : 小児悪性腫瘍研究会記録 = Pediatric oncology 45(3), 307-311, 2008-09-25