JPLTのプロトコールに従って術前化学療法を施行した新生児肝芽腫の1例  [in Japanese] A case of neonatal hepatoblastoma treated by JPLT protocol  [in Japanese]

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Author(s)

    • 大植 孝治 OUE Takaharu
    • 大阪大学大学院医学系研究科 小児成育外科 Department of Pediatric Surgery, Osaka University Graduate School of Medicine
    • 山中 宏晃 YAMANAKA Hiroaki
    • 大阪大学大学院医学系研究科 小児成育外科 Department of Pediatric Surgery, Osaka University Graduate School of Medicine
    • 谷 岳人 TANI Gakuto
    • 大阪大学大学院医学系研究科 小児成育外科 Department of Pediatric Surgery, Osaka University Graduate School of Medicine
    • 米田 光宏 YONEDA Akihiro
    • 大阪大学大学院医学系研究科 小児成育外科 Department of Pediatric Surgery, Osaka University Graduate School of Medicine
    • 時政 定雄 TOKIMASA Sadao
    • 大阪大学大学院医学系研究科小児科 Department of Pediatrics, Osaka University Graduate School of Medicine
    • 橋井 佳子 HASHII Yoshiko
    • 大阪大学大学院医学系研究科小児科 Department of Pediatrics, Osaka University Graduate School of Medicine
    • 太田 秀明 OHTA Hideaki
    • 大阪大学大学院医学系研究科小児科 Department of Pediatrics, Osaka University Graduate School of Medicine
    • 福澤 正洋 FUKUZAWA Masahiro
    • 大阪大学大学院医学系研究科 小児成育外科 Department of Pediatric Surgery, Osaka University Graduate School of Medicine

Abstract

症例は1か月男児.PRETEXT III肝芽腫の診断にて,JPLTプロトコールに従い薬剤投与量を30%に減量した化学療法を開始した.2コース終了後全摘術を施行し,術後2コースを追加した.治療終了時のAFPは月齢の正常値より高値であったが,順調に低下を示し,AFP-L3分画が正常化したこと,画像上腫瘍を認めないことから腫瘍残存無しと判断して治療を終了した.JPLTのプロトコールは生後1か月でも安全に施行でき,かつ有効であった.

A one-month-old boy with hepatoblastoma was treated according to the protocol of the Japanese Study Group for Pediatric Liver Tumor (JPLT). Serum alpha-fetoprotein was markedly elevated and the tumor occupied the most of the medial segment of the left lobe and part of the right lobe (PRETEXT III), therefore pre-operative chemotherapy was started. The anti-cancer agents were reduced to 30% of the standard adult dosage, because the toxicity is more increased in neonates and infants than in older children. After two courses of chemotherapy, the tumor size was decreased and complete tumor resection was safely performed. Two more courses of chemotherapy were added. Serum alpha-fetoprotein was decreased but was not in the normal range. However AFP-L3 was normalized and no tumor was detected by CT scan, therefore we terminated the treatment. The patient has been alive without the tumor for 2 years.

Journal

  • 小児がん : 小児悪性腫瘍研究会記録 = Pediatric oncology

    小児がん : 小児悪性腫瘍研究会記録 = Pediatric oncology 45(3), 307-311, 2008-09-25

    がんの子供を守る会

References:  6

Cited by:  1

Codes

  • NII Article ID (NAID)
    110007171738
  • NII NACSIS-CAT ID (NCID)
    AN00116159
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03894525
  • Data Source
    CJP  CJPref  NII-ELS  NDL-Digital 
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