小児がんに対するWT1ペプチドによるワクチン療法  [in Japanese] Feasibility of WT1 peptide vaccination for the treatment of refractory hematological and solid malignancies in children  [in Japanese]

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Author(s)

    • 澤田 明久 SAWADA Akihisa
    • 大阪府立母子保健総合医療センター 血液・腫瘍科 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 井上 雅美 INOUE Masami
    • 大阪府立母子保健総合医療センター 血液・腫瘍科 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 近藤 統 KONDO Osamu
    • 大阪府立母子保健総合医療センター 血液・腫瘍科 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 木本 富子 KIMOTO Tomiko
    • 大阪府立母子保健総合医療センター 血液・腫瘍科 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 山田 佳世 YAMADA Kayo
    • 大阪府立母子保健総合医療センター 血液・腫瘍科 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 中山 雅弘 NAKAYAMA Masahiro
    • 大阪府立母子保健総合医療センター検査科 Department of Pathology and Clinical Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 桑江 優子 KUWAE Yuko
    • 大阪府立母子保健総合医療センター検査科 Department of Pathology and Clinical Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 西川 正則 NISHIKAWA Masanori
    • 大阪府立母子保健総合医療センター放射線科 Department of Radiology, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 土屋 邦彦 TSUCHIYA Kunihiko
    • 京都府立医科大学大学院医学研究科 Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
    • 窪田 昭男 KUBOTA Akio
    • 大阪府立母子保健総合医療センター 小児外科 Department of Pediatric surgery, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 川原 央好 KAWAHARA Hisayoshi
    • 大阪府立母子保健総合医療センター 小児外科 Department of Pediatric surgery, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 長谷川 利路 HASEGAWA Toshimiti
    • 大阪府立母子保健総合医療センター 小児外科 Department of Pediatric surgery, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 米田 光宏 YONEDA Akihiro
    • 大阪府立母子保健総合医療センター 小児外科 Department of Pediatric surgery, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 竹本 理 TAKEMOTO Osamu
    • 大阪府立母子保健総合医療センター脳神経外科 Department of Neurosurgery, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 山田 淳二 YAMADA Junji
    • 大阪府立母子保健総合医療センター脳神経外科 Department of Neurosurgery, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 川端 秀彦 KAWABATA Hidehiko
    • 大阪府立母子保健総合医療センター整形外科 Department of Orthopaedic surgery, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 田村 太資 TAMURA Daisuke
    • 大阪府立母子保健総合医療センター整形外科 Department of Orthopaedic surgery, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 木内 恵子 KINOUCHI Keiko
    • 大阪府立母子保健総合医療センター麻酔集中治療科 Anesthesia and Intensive Care, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 平野 慎也 HIRANO Shinya
    • 大阪府立母子保健総合医療センター臨床試験支援室 Clinical Trials Office, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 宇野 誠 UNO Makoto
    • 大阪府立母子保健総合医療センター薬剤部 Pharmacy, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 多和 昭雄 TAWA Akio
    • 国立病院大阪医療センター 小児科 Department of Pediatrics, National Hospital Organization Osaka National Hospital
    • 尾路 祐介 OJI Yusuke
    • 大阪大学大学院医学系研究科 機能診断科学 Department of Functional Diagnostic Science, Osaka University Graduate school of Medicine
    • 坪井 昭博 TSUBOI Akihiro
    • 大阪大学大学院医学系研究科癌ワクチン療法学 Department of Cancer Immnotherapy, Osaka University Graduate school of Medicine
    • 小山 真穂 KOYAMA Maho
    • 大阪府立母子保健総合医療センター 血液・腫瘍科 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 岡 芳弘 OKA Yoshihiro
    • 大阪大学大学院医学系研究科癌ワクチン療法学 Department of Cancer Immnotherapy, Osaka University Graduate school of Medicine
    • 安井 昌博 YASUI Masahiro
    • 大阪府立母子保健総合医療センター 血液・腫瘍科 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health
    • 杉山 治夫 SUGIYAMA Haruo
    • 大阪大学大学院医学系研究科 機能診断科学 Department of Functional Diagnostic Science, Osaka University Graduate school of Medicine
    • 河 敬世 KAWA Keisei
    • 大阪府立母子保健総合医療センター 血液・腫瘍科 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health

Abstract

手術や放射線,化学療法,造血幹細胞移植などの従来法では根治が期待できない小児白血病,悪性固形腫瘍に対し,WT1ペプチド接種による免疫療法の安全性と有効性を検討した.対象は15例16コース.副作用は局所反応のみで,腫瘍残存例11コース中,臨床的効果を3例に,寛解を1例に認めた.腫瘍量が多いと臨床的効果が得難く,微少腫瘍量で開始できるように,難治例・再発例では治療早期から準備を進める必要がある.

Purpose: The purpose of this study is to evaluate the safety and efficacy of cancer immunotherapy with WT1 peptide for the treatment of children with refractory hematological and solid malignancies. Methods: The major eligible critria were the expression of the WT1 gene in affected tissues or leukemic cells, and the HLA type of the patients (and donors) being A2402. Vaccination using high-affinity WT1 peptide (CYTWNQMNL) with adjuvant (montanide ISA51) was performed every week for a tatl of 12 times. Results: 15 cases (16 courses) were enrolled. No side effects other than local skin reactions were observed. Out of the 10 cases (11 courses) having measurable residuals, clinical effects were observed in 3 cases, and there was complete remission in 1 case. Massive residual tumors or hematological leukemic burden were correlated with failure in the current setting. Conclusions: WT1 peptide vaccination was performed without serious complications in the present phase I/II study. In order to improve outcomes, WT1 peptide vaccination should be started at the earliest stages of the disease so that there are minimal lingering effects after successfully compteting therapy.

Journal

  • 小児がん : 小児悪性腫瘍研究会記録 = Pediatric oncology

    小児がん : 小児悪性腫瘍研究会記録 = Pediatric oncology 46(1), 6-16, 2009-02-25

    がんの子供を守る会

References:  26

Cited by:  1

Codes

  • NII Article ID (NAID)
    110007171798
  • NII NACSIS-CAT ID (NCID)
    AN00116159
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03894525
  • Data Source
    CJP  CJPref  NII-ELS  NDL-Digital 
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