Is Vitamin E Beneficial for Disease Prevention? : Assessment by Intervention Study and Biomarkers

• Niki Etsuo

  Health Technology Research Center

• Abe Kouichi

  Vitamin E Information and Technology Section, Eisai Co., Ltd:College of Pharmacy, Nihon University

Bibliographic Information

Other Title

• ビタミンEは疾患予防に対して有効か? : 介入試験とバイオマーカーに基づく評価
• ビタミン E ワ シッカン ヨボウ ニ タイシテ ユウコウ カ カイニュウ シケン ト バイオマーカー ニ モトズク ヒョウカ

Abstract

It is now accepted that lipid peroxidation is involved in the pathogenesis of various disorders and diseases and that vitamin E acts as a potent antioxidant against lipid peroxidation. However, the prospective randomized clinical trials have not shown consistently the beneficial effects of vitamin E on the prevention of diseases. To the contrary, meta-analysis of these studies suggests vitamin E supplementation at high doses may increase mortality. The results of these studies and possible problems are discussed. In order to provide sound scientific evidence for the effects of vitamin E, it is essential to carry out carefully-planned intervention study and to assess the effects continuously with appropriate biomarkers, not by single end point.

Journal

• VITAMINS

  VITAMINS 83 (5-6), 229-247, 2009

  THE VITAMIN SOCIETY OF JAPAN

Keywords

• vitamin E
• intervention study
• biomarkers
• disease prevention
• antioxidant

Details

• CRID: 1390001205701462656
• NII Article ID: 110007338143
• NII Book ID: AN00207833
• DOI: 10.20632/vso.83.5-6_229
• ISSN: 2424080X
• ISSN: 0006386X
• NDL BIB ID: 10356756
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10356756
• Web Site: https://search.jamas.or.jp/link/ui/2009260374
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed