二酸化珪素の遺伝子突然変異性および染色体異常誘起性 Mutagenic and Clastogenic Potentials of Silicon Dioxide

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Abstract

二酸化珪素(SiO<sub>2</sub>)は、日本では1991年食品添加物として認可され、主に粉末食品の固結防止剤として、食塩、砂糖、粉乳、インスタントココア等に広く加えられている。今まで、SiO<sub>2</sub>の短期および長期経口毒性や発がん性については動物実験で検討されており、安全性の高い物質であることが報告されている。しかし、変異原性に関する報告はほとんどないため、化学物質の発がん性のスクリーニング法として、広く行われているAmes testおよびMicronucleus testを行った。Ames testは化学物質の遺伝子突然変異性を、Micronucleus testは染色体異常誘起性を調べる試験法である。SiO<sub>2</sub>について2つの試験法により変異原性を検討した結果、いずれも陰性対照物質と差がなく、また量・反応関係も認められなかった。したがって、SiO<sub>2</sub>は変異原性を有しない物質と推定される。

Silicon dioxide (SiO<sub>2</sub>) was designated as a food additive in 1983. It is added to salt, sugar, milk powder, instant cocoa, etc. as an anticaking agent mainly for powdered foods. The short- and long-term oral toxicities and carcinogenicity of SiO<sub>2</sub> have been investigated in animal experiments and it has been reported that SiO<sub>2</sub> is a highly safe substance. However, there have been very few reports of its mutagenic potential. Therefore, we conducted the Ames test and the micronucleus test, both of which have been generally used as screening tests for carcinogenesis of chemicals. The Ames test and the micronucleus test are methods for evaluating the abilities of chemicals to induce gene mutations and chromosomal aberrations, respectively. These two tests for the mutagenic potential of SiO<sub>2</sub> showed that there was no significant difference between SiO<sub>2</sub> and the negative control. There was no dose-response relationship, either. Therefore, it is presumed that SiO<sub>2</sub> has no mutagenic activity.

Journal

  • Japanese Journal of Food Chemistry and Safety

    Japanese Journal of Food Chemistry and Safety 10(3), 133-137, 2003

    Japanese Society of Food Chemistry

References:  9

Codes

  • NII Article ID (NAID)
    110007367274
  • NII NACSIS-CAT ID (NCID)
    AA11666400
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    1341-2094
  • Data Source
    CJP  NII-ELS  J-STAGE 
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