Matrix metalloproteinase 1 produced by CXCL12 stimulation on NK92 cells

• Inoue Hiroshi

  Department of Physiology, Osaka Dental University

• Goda Seiji

  Department of Biochemistry, Osaka Dental University

• Domae Naochika

  Department of Internal Medicine, Osaka Dental University

• Nosaka Ko

  Department of Physiology, Osaka Dental University

• Nakai Masanori

  Department of Physiology, Osaka Dental University

• Uchihashi Kenji

  Department of Physiology, Osaka Dental University

• Nishikawa Yasuo

  Department of Physiology, Osaka Dental University

抄録

Natural killer (NK) cells play a key role in inflammation and tumor regression through their ability to migrate into tissues. The two major subsets in NK cells are CD56^bright CD16^dim/- and CD56^dim CD16⁺. The cytotoxic activity of CD56^dim NK cells is significantly greater than that of CD56^bright cells. Regarding cytokine production, the situation is inverted. CD56^bright NK cells are the most efficient cytokine producers. The role of CD56^bright CD16^- cells is not clear. CXCL12 is a chemokine that promotes Iymphocyte invasion and migration into tissues; however, the mechanism for this process remains incompletely understood. This study demonstrated that the NK92 cell population, which is the human NK cell line, was CD56^bright CD16^-. We examined the production of pro-matrix metalloproteinase (MMP) 1 induced by CXCL12 stimulation on NK92 cells. Pro-MMP 1 production was significantly enhanced by CXCL12 stimulation. In addition, the production of pro-MMP 1 was markedly inhibited by SB203580 (p38 inhibitor). These results suggest that p38, which is the family of mitogen activated protein kinases (MAPKs), was involved in the production of pro-MMP 1 from CXCL12-stimulated CD56^bright CD16^- NK92 cells.

収録刊行物

• Journal of Osaka Dental University

  Journal of Osaka Dental University 43 (2), 163-167, 2009

  大阪歯科学会

キーワード

• Natural killer (NK) cell
• CXCL12
• Matrix metalloproteinase (MMP)1

詳細情報

• CRID: 1390282679938572800
• NII論文ID: 110007386259
• NII書誌ID: AA00704144
• DOI: 10.18905/jodu.43.2_163
• ISSN: 21896488
• ISSN: 04752058
• Web Site: https://search.jamas.or.jp/link/ui/2010097666
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可