ヒト大腸癌悪性度評価におけるMMP-2,-9, E-cadherin発現の臨床的意義  [in Japanese] Clinical Significance of Matrix Metalloproteinase (MMP)-2, -9 and E-cadherin Expression for Assessing the Spreading of Human Colorectal Cancer  [in Japanese]

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Author(s)

    • 中澤 哲 NAKAZAWA Satoru
    • 東京女子医科大学医学部第二外科学 Departments of Surgery II, Tokyo Women's Medical University, School of Medicine
    • 齋藤 登 SAITO Noboru
    • 東京女子医科大学医学部第二外科学 Departments of Surgery II, Tokyo Women's Medical University, School of Medicine
    • 小林 槇雄 KOBAYASHI Makio
    • 東京女子医科大学医学部第一病理学 Departments of Pathology I, Tokyo Women's Medical University, School of Medicine

Abstract

Expression of matrix metalloproteinase (MMP)-2,-9 and E-cadherin was assessed serologically (peripheral blood) and immunohistologically to determine whether these parameters are useful in evaluating the preoperative malignancy of colon cancer and, in particular, predicting the onset of hepatic metastasis in the following patients: 30 colon cancer patients with synchronous hepatic metastases; 15 colon cancer patients with asynchronous hepatic metastases; and 114 colon cancer patients with matching clinicopathological factors who had not had recurrence for at least five postoperative years. Compared to the 114 colon cancer patients, MMP-2 expression was significantly higher in the patients with preoperative synchronous or asynchronous metastases, but there was no significant difference in MMP-9 expression. E-cadherin expression was also significantly higher in the patients with preoperative synchronous metastases. Prognosis was significantly poorer for patients with preoperative serum MMP-2 and E-cadherin levels above the cutoff value (mean + SD). In addition, the results of immunohistological analyses showed the same staining patterns for MMP-2 and -9 for 18 patients and were positive for all patients with infiltrative cancer. In particular, patients with hepatic metastasis showed high MMP-2 expression in tissue and serum. Considering serological and immunohistological findings of MMP-2, expression can be useful in assessing malignancy and predicting the risk for hepatic metastases.

Journal

  • Journal of Tokyo Women's Medical College

    Journal of Tokyo Women's Medical College 74(1), 26-32, 2004-01

    Tokyo Women's Medical University

Codes

  • NII Article ID (NAID)
    110007525769
  • NII NACSIS-CAT ID (NCID)
    AN00161368
  • Text Lang
    JPN
  • Article Type
    journal article
  • Journal Type
    大学紀要
  • ISSN
    0040-9022
  • NDL Article ID
    025920735
  • NDL Call No.
    Z19-400
  • Data Source
    NDL  NII-ELS  IR 
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