大腸癌低分化腺癌における臨床病理学的検討

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タイトル別名
  • ダイチョウ ガン テイブンカセンガン ニ オケル リンショウ ビョウリガクテキ ケントウ
  • Clinicopathological Study on Poorly Differentiated Colorectal Adenocarcinoma

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To elucidate clinical problems in the poorly differentiated colorectal cancer patients, we have studied both clinical as well as histological features in these patients. Among 752 colorectal cancer patients who have been operated in our department, we have experienced 42 patients (5.6%) with poorly differentiated adenocarcinoma. In analytical study of these patients, we have found that many of them tended to have tumor in the right-sided colon and presumably due the high prevalence of having the invasive legion, their curability was classified into grade C. They also have a high prevalence of the recurrence resulted in a low cumulative survival rate. Their accurate diagnosis before the operation was 25.8%. A reason of this difficulty in the making an accurate diagnosis might be due to the presence of the inflammatory lesion as well as non-poorly-differentiated cancer cells on the surface of their tumor tissues. Regarding the effect of post-operative chemotherapy, we found that a prolongation of their survival rate was found in patients who had been treated with the combination of leucovorin (LV) and 5-fluorouracil in comparison with those with other post-operative chemotherapies. Thus, because of such poor prognosis in these patients, the establishments of the accurate diagnosis procedure as well as a new therapeutic strategy are urgently required in these patients.

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