腸管出血性大腸菌(病原性大腸菌O157)感染症(新興・再興感染症,シンポジウム,東京女子医科大学学会第63回総会特集)

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  • Enterohemorrhagic Escherichia coli O157:H7 infection(Emerging and re-emerging diseases,Symposium)

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In 1996, an unexpectedly large number of outbreaks due to Escherichia coli 0157:H7 occurred in our country. A total of 22 were reported from May through October. Among them one outbreak at Sakai City in July and August was extremely large and more than 5,700 patients with 3 deaths were reported. A unique characteristic of these outbreaks was that 8 of 22 occurred in primary and secondary schools due to luncheons provided by schools. One of the most important characteristics of E. coli 0157:H7 is its production of Vero toxins (or Shiga-like toxins). Symptoms or complications of E. coli 0157:H7 infection, such as hemorrhagic colitis and hemolytic uremic syndrome, are caused by Vero toxins. It is reported that antibiotic therapy, such as that with fosfomycin, is effective to prevent a possible development of hemorrhagic uremic syndrome.

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