Role of Histamine in Atherosclerotic Lesions

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  • WANG Ke-Yong
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health
  • TANIMOTO Akihide
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences
  • SASAGURI Yasuyuki
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health

Bibliographic Information

Other Title
  • 動脈硬化病変におけるヒスタミンの役割
  • ドウミャク コウカ ビョウヘン ニ オケル ヒスタミン ノ ヤクワリ

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Abstract

Histamine is synthesized from L-histidine by histidine decarboxylase and is involved in a variety of physiologic responses, such as inflammation, type I allergy, gastric acid secretion and neurotransmission. In the arteriosclerotic lesions, histamine produced by macrophage-derived foam cells acts on smooth muscle cells, endocrine cells and inflammation cells through the specific histamine receptors and regulates the expression of many molecules concerned with inflammatory reaction. A regulatory system of chronic inflammatory reaction by the histamine network is involved in the formation and development of arteriosclerosis.

Journal

  • Journal of UOEH

    Journal of UOEH 32 (1), 63-71, 2010

    The University of Occupational and Environmental Health, Japan

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