Heart rate response to oxygen uptake during graded exercise as an index of cardiopulmonary functional reserve in patients on hemodialysis

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  • Watanabe,Shinichi
    Faculty of Creative Engineering, Kanagawa Institute of Technology:Development Center to Support Health and Welfare, Kanagawa Institute of Technology
  • Tsuyuki,Kazuo
    Development Center to Support Health and Welfare, Kanagawa Institute of Technology:Odawara Cardiovascular Hospital
  • Takahashi,Katsumi
    Faculty of Creative Engineering, Kanagawa Institute of Technology:Development Center to Support Health and Welfare, Kanagawa Institute of Technology
  • Ebine,Kunio
    Odawara Cardiovascular Hospital
  • Sakamoto,Takako
    Odawara Cardiovascular Hospital
  • Matsuo,Takashi
    Faculty of Creative Engineering, Kanagawa Institute of Technology:Development Center to Support Health and Welfare, Kanagawa Institute of Technology
  • Niizeki,Kyuichi
    Faculty of Engineering, Yamagata University
  • Takahashi,Tatsuhisa
    Department of Mathematical Information Science, Asahikawa Medical College

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Other Title
  • 慢性血液透析患者における心肺予備能の指標としての運動時酸素摂取量に対する心拍応答

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Abstract

The purpose of this study was to investigate the validity of inclination of exponential curve-fitting model for oxygen uptake and heart rate during graded exercise (I-ECOH) as index of cardiopulmonary functional reserve in patients on chronic hemodialysis (HD). Thirty patients on HD performed cardiopulmonary exercise test on a treadmill. I-ECOH was derived from the following equation: HR=A・exp^<B・VO2>, where HR was heart rate, VO_2 was oxygen uptake, and a constant "B" represented I-ECOH. The correlation coefficients for the relationship between VO_2 and HR through the maximal and submaximal exercises were above 0.95 in the exponential regression model. I-ECOH obtained during maximal and maximum VO_2 (VO_2max) were closely correlated (r=-0.89, p<0.001). I-ECOH obtained using submaximal exercise data (60-90%HRmax) was significantly correlated with VO_2max (p<0.001). There was no significant difference in I-ECOH between maximal and submaximal exercises data. These results suggested that I-ECOH was applicable to patients on HD as an objective by exercise and maybe useful marker for effort-independent estimation of cardiopulmonary functional reserve.

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