Effect of long acting nitric oxide donors on the differentiation of osteoclasts derived from mouse bone marrow macrophages

DOI 参考文献16件
  • Inami Kaoru
    Department of Orthodontics, Osaka Dental University
  • Sawai Hirofumi
    Department of Internal Medicine, Osaka Dental University
  • Katao Yuko
    Graduate School of Dentistry (Orthodontics), Osaka Dental University
  • Shishido Mika
    Graduate School of Dentistry (Orthodontics), Osaka Dental University
  • Ujii Yousuke
    Graduate School of Dentistry (Orthodontics), Osaka Dental University
  • Shimozuma Misa
    Graduate School of Dentistry (Orthodontics), Osaka Dental University
  • Nobata Kensuke
    Graduate School of Dentistry (Orthodontics), Osaka Dental University
  • Domae Naochika
    Department of Internal Medicine, Osaka Dental University
  • Mastumoto Naoyuki
    Department of Orthodontics, Osaka Dental University

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It is well established that osteoclast differentiation/activation is involved in orthodontic tooth movement at compression sites. However, the mechanism of osteoclast differentiation/activation in orthodontic tooth movement remains unclear. Nitric oxide (NO) has been reported to play a crucial role in bone remodeling induced by mechanical loading, and several reports have shown that inhibition of NO syntheses prevents orthodontic tooth movement in animal models. We investigated whether osteoclast differentiation can be induced by NO in vitro. We found that sustained release of NO by NOC-18 induces osteoclast differentiation of not only RAW264 cells but also bone marrow macrophages, and that the inhibition of ERK and activation of p38 MAPK may be involved in NOC-18-induced osteoclast differentiation.

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