歯髄創傷治癒に及ぼすエムドゲイン^【○!R】ゲルの影響

• 阿南 壽

  福岡歯科大学口腔治療学講座歯科保存学分野

• 松本 典祥

  福岡歯科大学口腔治療学講座歯科保存学分野

• 泉 利雄

  福岡歯科大学口腔治療学講座歯科保存学分野

• 松浦 洋志

  福岡歯科大学口腔治療学講座歯科保存学分野

• 諸冨 孝彦

  福岡歯科大学口腔治療学講座歯科保存学分野

• 榮田 太郎

  福岡歯科大学口腔治療学講座歯科保存学分野

• 茂山 千英子

  福岡歯科大学口腔治療学講座歯科保存学分野

• 國本 俊雄

  福岡歯科大学口腔治療学講座歯科保存学分野

• 福田 泰子

  福岡歯科大学口腔治療学講座歯科保存学分野

• 西村 彰弘

  福岡歯科大学口腔治療学講座歯科保存学分野

• 久原 裕子

  福岡歯科大学口腔治療学講座歯科保存学分野

書誌事項

タイトル別名

• The effects of Emdogain^【○!R】 gel on wound healing of rat dental pulp

抄録

The aim of this study was to investigate the effects of Emdogain^[○!R] gel (EMD) on injured pulp tissue. After Pulpotomy was performed in the mandibular first molars of rats, EMD or calcium hydroxide (Ca(OH)_2) was applied to the exposed pulp tissue. The treated teeth were extracted after 7, 14 and 28 days and prepared for histochemical examination. In the EMD-treated rats, few cells expressed IL-1β throughout the experimental period, but cells expressing BMP-4 rapidly increased in number. Newly formed reparative dentin was observed earlier and larger in amount than that seen in the Ca(OH)_2-treated rats. On the other hand, in the Ca(OH)_2-treated rats, numerous macrophages expressing IL-1β were first observed around the abscess, and then cells expressing BMP-4 gradually increased in number with the reparative dentin formation. These results suggest that there may be a difference in the time and extent of expression of cytokine and growth factors between EMD and Ca(OH)_2-treated rats. It is speculated that EMD scarcely irritates injured pulp tissue, and may have the benefit efficacy to create a favorable environment promoting wound healing of the injured pulp tissue.

収録刊行物

• 福岡歯科大学学会雑誌

  福岡歯科大学学会雑誌 36 (3), 119-127, 2010-09-30

  福岡歯科大学学会

キーワード

• Emdogain
• dental pulp
• wound healing
• macrophage
• BMP-4

詳細情報

• CRID: 1573105977377240192
• NII論文ID: 110007817663
• NII書誌ID: AN00216288
• ISSN: 03850064
• Web Site: https://search.jamas.or.jp/link/ui/2011031778
• 本文言語コード: ja
• データソース種別:
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