S0201-2-5 単離骨系細胞間におけるカルシウム応答伝播の非対称性(マイクロ・ナノバイオメカニクス:細胞生物学への接近(2)刺激と応答)

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  • S0201-2-5 Asymmetry in calcium signal propagation among isolated bone cells

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Bone remodels its structure under changing mechanical environment. It is widely recognized that osteocytes (Ocy) embedded in bone matrix sense changes in their mechanical environment, and bone surface cells (BSC) such as osteoblasts are followed by new bone formation. From this point of view, various studies have observed response of Ocy and BSC to biochemical and mechanical stimulation. However, the characteristics of communication among these cells have not been clearly understood. In this study, we observed the calcium signal propagation, in response to local applied deformation using a glass microneedle, among bone cells isolated from chick calvaria. As a result, BSC received calcium signaling more sensitively than Ocy, regardless of the cell type of transmitter. This suggests that, in living bone tissue matrix, cellular communications occur near the bone surface, and bone functional adaptation by remodeling may refer to the mechanical environment of particularly bone surface. This result could provide us a new insight into the intercellular signal transduction among bone cells.

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