S0201-2-6 ストレスファイバの破壊が線維芽細胞の引張特性に及ぼす影響(マイクロ・ナノバイオメカニクス:細胞生物学への接近(2)刺激と応答)

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  • S0201-2-6 Effect of disruption of central stress fibers on the tensile properties of fibroblasts

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Tensile properties of fibroblasts obtained from rabbit patellar tendons were determined after their central stress fibers were disrupted with Y-27632. Each cell was attached to the fine tips of a micropipette and a glass microplate, and stretched at the rate of 6 imfs. The initial stiffness of cells, defined as the slope of each load-elongation curve between 0 and 20 μm elongation, decreased by 29% after the central stress fibers were disrupted. In the previous study, we reported that the initial stiffness was decreased by 73% by the disruption of actin filaments including actin meshworks and actin bundles such as stress fibers. These results suggest that both central stress fibers and actin meshworks beneath cell membrane greatly affect the tensile properties of fibroblasts.

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