フッ化ジアミンシリケートの象牙質知覚過敏症治療剤への応用 : 溶液濃度が象牙細管封鎖能に及ぼす影響の検討  [in Japanese] Application of Ammonium Hexafluorosilicate for the Treatment of Dentin Hypersensitivity : Evaluation of Relationship between Ammonium Hexafluorosilicate Concentration and Occlusion of Dentin Tubules  [in Japanese]

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Author(s)

    • 菅 俊行 SUGE Toshiyuki
    • 徳島大学大学院ヘルスバイオサイエンス研究部発達予防医歯学部門健康長寿歯科学講座歯科保存学分野 Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School
    • 柴田 眞吾 SHIBATA Shingo
    • 徳島大学大学院ヘルスバイオサイエンス研究部発達予防医歯学部門健康長寿歯科学講座歯科保存学分野 Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School
    • 松尾 敬志 MATSUO Takashi
    • 徳島大学大学院ヘルスバイオサイエンス研究部発達予防医歯学部門健康長寿歯科学講座歯科保存学分野 Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School

Abstract

フッ化ジアンミン銀(サホライド®)の歯質着色の問題点を改良する目的で,フッ化ジアミンシリケート溶液( (NH<sub>4</sub>)<sub>2</sub>SiF<sub>6</sub>)を調製した.これまでの研究では,ほかのフッ素化合物と比較検討するために酸性リン酸フッ素溶液と同濃度に調製した9,000ppm濃度の溶液を用いて研究を遂行してきた.そのため,9,000ppm濃度以外の溶液を使用した場合の象牙細管封鎖能は不明である.本研究の目的は,各種濃度のフッ化ジアミンシリケート溶液処理後の象牙細管封鎖能を評価することにより,臨床で使用する際の最適な濃度を探索することである.各種濃度(100〜19,400ppmまで)のフッ化ジアミンシリケート溶液を調製して,ヒト抜去歯から作製した象牙質プレートに塗布し,SEM観察することによって象牙細管封鎖効果の評価を行った.また各種濃度のフッ化ジアミンシリケート溶液処理後に象牙細管内に析出した結晶の組成は,エネルギー分散型X線マイクロアナライザー(EDXA)にて分析を行った.SEM観察の結果,フッ化ジアミンシリケート溶液濃度にかかわらず,開口象牙細管は結晶性物質により緊密に封鎖されていた.EDXAにより象牙細管内に析出した結晶の組成を分析した結果,フッ化ジアミンシリケート溶液濃度に比例して,カルシウムとリンのモル比が1.5(100ppm溶液処理後)から2.1(19,400ppm溶液処理後)に上昇していた.フッ化ジアミンシリケート溶液は100〜19,400ppm濃度までいずれの濃度の場合においても象牙細管を緊密に封鎖したが,象牙細管内に析出した結晶の組成は変化しており,高濃度の場合には結晶中に占めるフッ化カルシウムの量が上昇していることが推察された.

Ammonium hexafluorosilicate (SiF: (NH<sub>4</sub>)<sub>2</sub>SiF<sub>6</sub>) was prepared in order to overcome the tooth discoloration caused by diamine silver fluoride (Saforide®). In our previous study, a constant concentration of SiF solution (9,000ppm) was used to compare its fluoridation effect with that of acidulated phosphate fluoride (APF). Therefore, the effects of the concentration of SiF solution on the occlusion of dentin tubules and composition of the precipitate remain unclear. Thus, the aim of this study was to evaluate the effects of changing the concentration of SiF on its clinical application as a dentin hypersensitivity treatment. Several SiF solution concentrations (from 100 to 19,400ppm) were prepared. Occlusion after treatment with these SiF solutions was evaluated using human dentin disks. The surface of dentin disks was observed using scanning electron microscopy (SEM). Also, the composition of the precipitate formed in dentin tubules after being treated with the SiF solutions was analyzed with energy dispersive X-ray microanalysis (EDXA). SEM observation showed that open dentin tubules were completely occluded irrespective of the concentration of SiF solution. EDXA analysis showed that the Ca/P molar ratio of the precipitate formed in the dentin tubules after SiF treatment gradually increased from 1.5 (100ppm SiF solution) to 2.1 (19,400ppm SiF solution) with the concentration of SiF solution. It was concluded that the occlusion of dentin tubules upon SiF treatment was the same irrespective of the concentration of the SiF solution. However, the composition of the precipitate formed in dentin tubules was governed by the concentration of the SiF solution.

Journal

  • The Japanese Journal of Conservative Dentistry

    The Japanese Journal of Conservative Dentistry 52(6), 446-452, 2009

    The Japanese Society of Conservative Dentistry

References:  16

Codes

  • NII Article ID (NAID)
    110007880692
  • NII NACSIS-CAT ID (NCID)
    AN00191201
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    0387-2343
  • Data Source
    CJP  NII-ELS  J-STAGE 
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