自然発症2型糖尿病ラット歯肉の末梢血管の変化に関する研究  [in Japanese] Study of the Change in the Peripheral Artery of Spontaneously Diabetic Rat's Gingiva  [in Japanese]

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Author(s)

    • 千葉 朋義 CHIBA Tomoyoshi
    • 日本歯科大学新潟生命歯学部歯周病学講座 Department of Periodontology, School of Life Dentistry at Niigata, The Nippon Dental University
    • 佐藤 聡 SATO Soh
    • 日本歯科大学新潟生命歯学部歯周病学講座 Department of Periodontology, School of Life Dentistry at Niigata, The Nippon Dental University

Abstract

糖尿病は糖代謝の異常によって起こる疾患で,血液中のブドウ糖濃度が病的に高まることによって網膜症,腎症,神経障害など特徴的な合併症をきたすことが知られている.さらに糖尿病による口腔内の変化としては,これまで唾液分泌量の低下から起こる口腔乾燥症や歯周病の発症または重症化などについて多く報告されている.このような糖尿病下にある患者の治療では,細小血管症やアシドーシス,さらに糖・タンパク代謝異常などから治療の侵襲に対する抵抗力の減弱と併せて,創傷治癒の遅延を生じるとされている.そこで,糖尿病が歯周組織中の末梢血管に及ぼす影響について組織学的ならびに生化学的に検討を加える目的で,ラット口蓋歯肉のサブスタンスP受容体(NK1R)ならびに,血管作働性小腸ペプチド(VIP)受容体1(VIPR1)の分布について免疫組織化学的に,さらに歯肉中のタンパク発現量について検討を加えた.その結果,2型糖尿病ラットの歯肉内のNK1RとVIPR1は,毛細血管周囲に強く,上皮下の炎症性細胞が確認された結合組織中に一致して局在が確認された.さらにVIPR1は,糖尿病罹患下で有意に減少していた.

Diabetes is a disease that develops due to an abnormal metabolism and is characterized by various complications, such as retinopathy, kidney disease, and neurological impairment, due to pathologically high concentrations of glucose in the blood. There have been many reports so far on the oral changes due to diabetes, such as the onset or exacerbation of dry mouth and periodontal disease caused by a decrease in the volume of saliva secretion. When treating patients with diabetes, it is believed that delayed wound healing occurs in conjunction with a weakening of the patient's resistance to the invasion associated with the treatment due to microvascular disease, acidosis, and abnormal glucose and/or protein metabolism. Therefore, the aim of the present study was to histologically and biochemically examine the effects of diabetes on peripheral vasculature in gingival tissue by determining immunohistochemically the distribution of substance P receptors (NK1R) in rat palatal gingiva and vasoactive intestinal peptide (VIP) receptor 1 (VIPR1), as well as the amount of protein produced in the gingiva. We found that the staining of NK1R and VIPR1 in the gingiva of type 2 diabetes rats was strong around the capillaries. We also observed both receptors in localized areas in connective tissue that was confirmed to have subepithelial inflammatory cells. Finally, VIPR1 was decreased significantly in diabetes.

Journal

  • The Japanese Journal of Conservative Dentistry

    The Japanese Journal of Conservative Dentistry 53(1), 15-24, 2010

    The Japanese Society of Conservative Dentistry

References:  45

Codes

  • NII Article ID (NAID)
    110007880707
  • NII NACSIS-CAT ID (NCID)
    AN00191201
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    0387-2343
  • Data Source
    CJP  NII-ELS  J-STAGE 
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