Age-related changes in collagen, laminin and tenascin in the infant rat submandibular gland

• Ito Yoshio

  Department of Biochemistry, Osaka Dental University

• Tamura Isao

  Department of Biochemistry, Osaka Dental University

抄録

We investigated biochemically and immunohistochemically the age-related changes in collagen (types I, III and IV), laminin and tenascin of the extracellular matrix in the submandibular gland of infant rats. The hydroxyproline content markedly increased on day 14 after birth. Electrophoretic profile revealed α chains of only type I collagen up to day six after birth. Type III collagen, which was diffusely distributed in interlobular connective tissue, was gradually expressed from day seven after birth. Type IV collagen content increased from day seven. Laminin content gradually increased with age. Tenascin immunohistochemically showed weak expression only around the vessel walls up to day seven. In addition, this expression markedly increased around acinar and ductal walls as basement membrane components on day 14 after birth.<br> These findings suggest that rat submandibular gland types I and IV collagen, and laminin are already present during the fetal stage and relate to construction of tissue, and that type III collagen and tenascin, which increased from day seven after birth, relate to maturation.

収録刊行物

• Journal of Osaka Dental University

  Journal of Osaka Dental University 31 (1_2), 19-27, 1997

  大阪歯科学会

キーワード

• Infant rat submandibular gland
• Collagen
• Laminin
• Tenascin

詳細情報

• CRID: 1390282679938144768
• NII論文ID: 110007987934
• NII書誌ID: AA00704144
• DOI: 10.18905/jodu.31.1_2_19
• ISSN: 21896488
• ISSN: 04752058
• Web Site: https://search.jamas.or.jp/link/ui/1998173514
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可