放射線照射後のラットにおける酸化ストレス値の経時変化  [in Japanese] Time series analysis of blood oxidative stress value in irradiated rats  [in Japanese]

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Author(s)

Abstract

Indirect effect of ionizing-radiation causes free radicals and reactive oxgen species (ROS). These ROS interact with DNA or other organella, and cause oxidative damage to nucleic acids, membrane lipoprotein, mitchondria and others.The purpose of this study is to evaluate oxidative damage by irradiation using d-ROMs test.Electron beam was irradiated to the thigh of Wistar strain female rats, and reactive oxygen metabolites in the blood from these rats were measured and analysed. From the results, 2Gy group shows significantly higher oxidative stress level than those of 0Gy group especially in day 3 after irradiation. This oxidative stress definitely seemed to be caused by exposure to ionizing-radiation. In contrast, the group of 30Gy-irradiation showed no significant increase of oxidative stress level. It was thought that oxidative stress caused by radiation was neutralized by expression of stress-induced antioxidant enzymes. These data resulted that d-ROMs test is useful for measuring oxidative stress levels of irradiated mammalian animals

Journal

  • Bulletin of Yamagata University Natural science

    Bulletin of Yamagata University Natural science 17(2), 31-39, 2011-02

    Yamagata University

Codes

  • NII Article ID (NAID)
    110008151157
  • NII NACSIS-CAT ID (NCID)
    AN0024300X
  • Text Lang
    JPN
  • Article Type
    departmental bulletin paper
  • Journal Type
    大学紀要
  • ISSN
    05134692
  • NDL Article ID
    11014904
  • NDL Source Classification
    ZM2(科学技術--科学技術一般--大学・研究所・学会紀要)
  • NDL Call No.
    Z14-258
  • Data Source
    NDL  NII-ELS  IR 
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