糖尿病とミトコンドリア機能 [in Japanese] Mitochondrial Function and Diabetes [in Japanese]
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Diabetes Mellitus is characterized as hyperglycemia, which is caused by insulin secretion deficit and insulin resistance. The significance of mitochondrial function in diabetes had thought to be a secondary factor for target organ dysfunction in patients with diabetes because of the vulnerability of mitochondrial genes by hyperglycemic condition. After finding that mitochondrial gene mutation induces diabetes; mitochondrial myopathy, encepharopathy, lactic acidosis and stroke-like episodes (MELAS), mitochondrial dysfunction have thought to be the principal cause of diabetes. Recently, it has become evident that mitochondrial function plays an important role for cell survival and maintenance of insulin secretion function using rodent and cultured cells. There is plurality of evidence for insulin resistance, although glucose uptake in liver need mitochondrial pathway. Interestingly, hyperinsulinemia in high lipid fed rats as a model of metabolic syndrome has also been reported to be related to mitochondrial function. Hepatocyte nuclear factor(HNF) 1 whose gene is reported to cause MODY3, affects mitochondrial membrane function in cells. Furthermore, we reported that Q268XHNF4 mutaion causes MODY1 and affects the mitochondrial pH reaction by glucose. The HNF4 gene is also reported to affect the susceptibility gene for type2 diabetes. Based on this, it can be concluded that diabetes can be said to some degree that it is a mitochondrial disease.
- Journal of Tokyo Women's Medical College
Journal of Tokyo Women's Medical College 81(臨時増刊(岩本安彦教授退任記念特別)), E85-E88, 2011-03-31
Tokyo Women's Medical University