内因性インスリン分泌が緩徐に枯渇していった肥満2型糖尿病の1例 [in Japanese] Inhibition of Endogenous Insulin Secretion due to Long-term Treatment for Type 2 Diabetes : A Case Report [in Japanese]
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We report a case of type 2 diabetes in which endogenous insulin secretion dried up during treatment which the patient had been undergoing for 26 years after the onset. We discussed the cause for the drying up of the endogenous insulin secretion ability and discussed future treatment to maintain the endogenous insulin secretion at an appopriate level. A 57 year-old woman was given a diagnosis of type 2 diabetes at 31 years old. At the time of diagnosis, the endogenous insulin secretion had already deteriorated and continued to dry up further for 2 years, and completely dried up after 26 years since the diagnosis. It is thought that insulin secretion dried up as a result of pregnancy and delivery, long-term hyper-glycemia, and obesity. A more strict glycemic control during pregnancy, using a combination of metformin or α- glucosidase inhibitor might have prevented the decrease of endogenous insulin secretion. Treatment to prevent decrease of endogenous insulin secretion in type 2 diabetes isnecessary.
- Journal of Tokyo Women's Medical College
Journal of Tokyo Women's Medical College 81(臨時増刊(岩本安彦教授退任記念特別)), E237-E240, 2011-03-31
Tokyo Women's Medical University