Bcl11b Heterozygous Mice are Susceptible to N-methyl-N-nitrosourea-induced Thymic Lymphomas

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  • NAKAO Rieko
    1Doctoral Course of Infection Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Department of Nursing, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
  • HONDA Sumihisa
    Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
  • MOJI Kazuhiko
    Research Institute for Humanity and Nature, Kyoto, Japan
  • ABE Yasuyo
    Research Institute for Humanity and Nature, Kyoto, Japan
  • AOYAGI Kiyoshi
    Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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  • Relationship between Lifestyle and Mental Health:A Population-Based Survey in Nagasaki Prefecture, Japan

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Objective: Mental health disorders among community dwelling Japanese people has not been well documented. The objective of the present study was to gain insights into the relationships between lifestyle factors and mental health in a community population. Methods: Associations between lifestyle factors and mental health were investigated in Nagasaki prefecture with a selfadministrated questionnaire including socio-demographic (age and sex), lifestyle (diet, exercise, sleep, smoking, alcohol drinking), and mental health factors. Results: A total of 2,146 people (1,052 men and 1,094 women) responded fully to the 12-item version of the General Health Questionnaire (GHQ-12). High GHQ-12 scores (defined as a score of ≥ 4, to indicate poor mental health) were more prevalent in women (18.9%) than in men (15.6%) (P=0.041). Moreover, the proportion of high GHQ-12 score was higher in the younger age group (20 to 39 years), comparing to other age groups. As the result of multiple logistic regression analysis, four variables were selected as factors associated with a high GHQ-12 score: women (odds ratio (OR): 1.3, 95% confidence interval (95% CI): 1.0-1.6); 20 to 39 years (OR: 2.5, 95% CI: 1.7-3.6) and 40 to 64 years (OR: 1.4, 95% CI: 1.0-1.9), both with ≥ 65 years as reference; not eating meals regularly (OR: 1.7, 95% CI: 1.2-2.4); and not getting enough sleep (OR: 2.8, 95% CI: 2.1-3.6). Conclusion: The findings indicate that the young and women are more likely to have poor mental health, and that lifestyle factors such as diet behavior and sleep are associated with mental health.

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