Diagnostic value of single photon emission computed tomography (SPECT) of the brain of patients with the first-episode schizophrenia(Basic medicine)

• Wake Rei

  Department of Psychiatry, Shimane University School of Medicine

• Miyaoka Tsuyoshi

  Department of Psychiatry, Shimane University School of Medicine

• Kawakami Kazunori

  Department of Psychiatry, Shimane University School of Medicine

• Furuya Motohide

  Department of Psychiatry, Shimane University School of Medicine

• Ieda Masa

  Department of Psychiatry, Shimane University School of Medicine

• Kristian Liaury

  Department of Psychiatry, Shimane University School of Medicine

• Tsuchie Keiko

  Department of Psychiatry, Shimane University School of Medicine

• Nishida Akira

  Department of Psychiatry, Shimane University School of Medicine

• Inagaki Takuji

  Department of Psychiatry, Shimane University School of Medicine

• Horiguchi Jun

  Department of Psychiatry, Shimane University School of Medicine

抄録

Objective: We attempted to identify the locus of cerebral blood flow reduction to clarify the functional neuroanatomical basis of the first-episode schizophrenia. A secondary objective was to evaluate the diagnostic value a new analytical program, easy Z-score Imaging System (eZIS). Method: We performed single photon emission computed tomography (SPECT) with 99-Tc-ethyl cysteinate dimmer (^<99m>Tc-ECD) of the brains of patients with the first-episode schizophrenia (n=30) and normal controls (n=37) and evaluated the diagnostic value of brain perfusion SPECT using eZIS on patients with schizophrenia. Result: In comparison with normal controls, the patients with schizophrenia were found to have reduced blood flow in bilateral frontal and temporal areas. Conclusion: In our study, patients with the first-episode schizophrenia appeared to have significant bilateral fronto-temporal hypoperfusion. Demonstration of abnormality of frontal and temporal lobe blood flow may assist in the diagnosis of schizophrenia and determination of appropriate treatment for individuals with schizophrenia.

収録刊行物

• 脳科学誌

  脳科学誌 36 (0), 4-17, 2011

  日本脳科学会

キーワード

• schizophrenia
• 99mTc-ECD
• SPECT
• hypoperfusion

詳細情報

• CRID: 1390001204921664000
• NII論文ID: 110008574011
• NII書誌ID: AA11081225
• DOI: 10.20821/jbs.36.0_4
• ISSN: 24322512
• ISSN: 13415301
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可