Effect of econazole on membrane calcium transport in rat thymocytes

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著者

    • Akiyama Jun Akiyama Jun
    • Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima
    • Yamashita Kohei
    • Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima
    • Shibagaki Haruka
    • Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima
    • Tanaka Fumika
    • Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima
    • Sakanashi Yoko
    • Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima
    • Oyama Yasuo
    • Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima

抄録

Econazole, one of azole antifungals, is proven to exhibit an inhibitory action on Mycobateriumtuberculosis and its multidrug-resistant strains under in vitro and ex vivo conditions. However, econazole has been used as a pharmacological tool for inhibiting capacitative Ca2+ influx and exerts multiple effects on cellular Ca2+ circumstance. Therefore, to suggest the toxic effect of econazole at therapeutic concentrations, we have tested on the effect on membrane Ca2+ transport in rat thymocytes by using a flow cytometer with Fluo-3, an indicator of intracellular Ca2+. Econazole at concentrations of 1-3 μM increased membrane Ca2+ permeability and inhibited capacitative Ca2+ influx without affecting passive Ca2+ influx, Ca2+ release from intracellular Ca2+store sites, and membrane Ca2+ pump. Econazole at 0.3 μM, a therapeutic concentration against tuberculosis caused by multidrug-resistant and latent M. tuberculosis, did not affect membrane Ca2+ transport. It may be suggested that econazole at therapeutic concentrations exerts no side effect related to Ca2+.

収録刊行物

  • 徳島大学総合科学部自然科学研究

    徳島大学総合科学部自然科学研究 23, 1-6, 2009

    徳島大学

各種コード

  • NII論文ID(NAID)
    110008699543
  • NII書誌ID(NCID)
    AN10065859
  • 本文言語コード
    ENG
  • 資料種別
    Departmental Bulletin Paper
  • 雑誌種別
    大学紀要
  • ISSN
    09146385
  • NDL 記事登録ID
    10783951
  • NDL 雑誌分類
    ZM1(科学技術--科学技術一般)
  • NDL 請求記号
    Z14-1395
  • データ提供元
    NDL  NII-ELS  IR 
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