Cytotoxic actions of lidocaine at sublethal concentrations : A model in vitro experiment using rat thymocytes

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In order to reveal some cytotoxic features of lidocaine, the effects of lidocaine at sublethalconcentrations (10 mM or less) on rat thymocytes were examined by the use of flow-cytometrictechnique with fluorescent probes. Treatment with lidocaine at 3-10 mM for 1-3 hrsignificantly increased intracellular Ca2+ and Zn2+ concentrations under normal condition.After the removal of external Ca2+ and Zn2+, lidocaine still increased intracellular Ca2+ and Zn2+concentrations, suggesting the lidocaine-induced release of intracellular Ca2+ and Zn2+.Treatment with lidocaine at 0.3-1 mM for 24 hr significantly increased the populations of deadcells and shrunken cells. Lidocaine at sublethal concentrations exerts some cellular actionsthat are supposed to be linked to the cytotoxicity. The mechanism of lidocaine-induced celldeath varies in time- and concentration-dependent manners.

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  • 徳島大学総合科学部自然科学研究

    徳島大学総合科学部自然科学研究 24, 1-5, 2010

    徳島大学

各種コード

  • NII論文ID(NAID)
    110008703785
  • NII書誌ID(NCID)
    AN10065859
  • 本文言語コード
    ENG
  • 資料種別
    Departmental Bulletin Paper
  • 雑誌種別
    大学紀要
  • ISSN
    09146385
  • NDL 記事登録ID
    023446492
  • NDL 請求記号
    Z14-1395
  • データ提供元
    NDL  NII-ELS  IR 
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