食後の血中トリアシルグリセロールの上昇に及ぼすアカショウマエキスの影響  [in Japanese] Effects of Astilbe thunbergii Rhizomes Extract on the Postprandial Blood Triacylglycerol Elevation  [in Japanese]

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Author(s)

Abstract

The present study investigated the effects of Astilbe thunbergii rhizome extract on pancreatic lipase activity in vitro. The 50% ethanol extracts of rhizomes of A. thunbergii (EATE) significantly inhibited pancreatic lipase activity in vitro. Furthermore, EATE was suspended in H_2O, and was chromatographed on a DIAION HP-20 column, and eluted with H_2O, methanol, successively. The fraction eluted with methanol significantly inhibited pancreatic lipase activity in vitro. In this experiment, EATE significantly reduced the elevation of rat plasma triacylglycerol level after oral administration of a lipid emulsion compared with that of rats given the lipid emulsion alone. Furthermore, we examined the effects of EATE on the plasma triacylglycerol and chylomicron levels of oral adiministration with a high-fat diet in humans. EATE reduced the plasma triacylglycerol and chylomicron levels compared with that of humans given the high-fat diet alone. Therefore, these results suggest that EATE may be an effective crude drug for the treatment of hyperlipidaemia caused by a high-fat diet.

Journal

  • The Japanese journal of pharmacognosy

    The Japanese journal of pharmacognosy 60(2), 68-72, 2006-08-20

    日本生薬学会

References:  7

Codes

  • NII Article ID (NAID)
    110008729780
  • NII NACSIS-CAT ID (NCID)
    AN10438628
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    13499114
  • NDL Article ID
    8066450
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z74-E874
  • Data Source
    CJP  NDL  NII-ELS  NDL-Digital 
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