Phenylethanoid Glycosides Targeting Mammalian DNA Polymerases

Access this Article

Author(s)

Abstract

In our continuing search to discover bioactive compounds from medicinal plants, a methanolic extract of Verbascum songaricum collected in Kazakhstan was investigated. Activity-guided fractionation of the extract prepared from the plant, using a sensitive assay to monitor DNA polymerase reactions, resulted in the isolation of two known phenylethanoid glycosides, poliumoside (1) and verbascoside (2). Glycoside 1 was shown to inhibit mammalian DNApolymerases α,β,δ and ε with IC_<50> values of 42, 23, 35 and 9 μM, respectively, while those of glycoside 2 were all more than 100 μM.

Journal

  • Natural medicines

    Natural medicines 57(4), 146-149, 2003-08-20

    日本生薬学会

References:  23

Codes

  • NII Article ID (NAID)
    110008732258
  • NII NACSIS-CAT ID (NCID)
    AN10438628
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    13403443
  • NDL Article ID
    6668105
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-375
  • Data Source
    CJP  NDL  NII-ELS  NDL-Digital 
Page Top