ウリジン二リン酸グルクロン酸転移酵素1A1の立体構造予測

• 小田, 彰史

• 小林, 佳奈

• 高橋, 央宜

書誌事項

タイトル別名

• Prediction of Three Dimensional Structure of Uridine Diphosphate Glucuronosyltransferate 1A1
• ウリジン 2リンサン グルクロンサン テンイ コウソ 1A1 ノ リッタイ コウゾウ ヨソク

抄録

In this study,we construct the three dimensional structure of Uridine Diphosphate Glucuronosyltransferate (UGT) 1A1 by using for template homology/analyogy recognition engine (phyre) server.Ten PDB entries including UGT2B7 were used for template of the model,and both UDP-glucuronic acid binding domain and substrate binding domain were obtained. By using the modeled structure,structural refinement was carried out by molecular dynamics (MD) simulations.In order to investigate the role of cysteine,MD simulations of both UGT1A1 models with and without the Cys127-Cys156 disulfide bond were performed.As the results of the simulations,structural features of UGT1A1 can be investigated, and refined structure of it was obtained.

収録刊行物

• 東北薬科大学研究誌

  東北薬科大学研究誌 (55), 85-90, 2008-12

  仙台 : 東北薬科大学

キーワード

• Uridine Diphosphate Glucuronosyltransferase;Structural Prediction;Drug Metabolism

詳細情報

• CRID: 1050001337603014400
• NII論文ID: 120005549207
• NII論文ID: 110008750893
• NII書誌ID: AA1149311X
• ISSN: 1345157X
• NDL書誌ID: 10315376
• Web Site: https://tohoku-mpu.repo.nii.ac.jp/records/123
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10315376
• 本文言語コード: ja
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • NDL
  • CiNii Articles
  • KAKEN