Zinc-pyrithione exerts diverse actions on human leukemia K562 cells : A preliminary study on hormetic action

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著者

    • Endo Yosuke Endo Yosuke
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Han Zhe-Hao Han Zhe-Hao
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Sakata Masahiro
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Maetaka Akinori
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Yonezawa Takayasu
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Koizumi Kazuki
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Oyama Yasuo
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima

抄録

Zinc-pyrithione is widely used as a topical agent. It may be likely that zinc-pyrithione possesses unique cytotoxic action because zinc exerts diverse actions on process of cell death. In this study, we examined the cytotoxicity of zinc-pyrithione on human leukemia K562 cells in order to examine the possibility of hormetic action. Zinc-pyrithione at concentrations ranging from 0.3 μM to 3 μM induced diverse actions on K562 cells. The agent at 0.3 and 1 μM significantly inhibited spontaneous occurrence of cell death during 72 h incubation while it was not the case for 3 μM. Significant decrease in population of shrunken cells was observed when the concentrations of zinc-pyrithione were 0.3 and 1 μM. Cell growth was significantly inhibited by 1 and 3 μM zinc-pyrithione, but not by 0.3 μM. Although the inhibition of cell growth by zinc-pyrithione was concentration-dependent, the inhibition of spontaneous cell death was observed only at lower concentrations (0.3 and 1 μM) of zinc-pyrithione. Results suggest that zinc-pyrithione possesses diverse actions, including hormetic action, on proliferative cells.

収録刊行物

  • 徳島大学総合科学部自然科学研究

    徳島大学総合科学部自然科学研究 25, 15-19, 2011

    徳島大学

各種コード

  • NII論文ID(NAID)
    110008761219
  • NII書誌ID(NCID)
    AN10065859
  • 本文言語コード
    ENG
  • 資料種別
    Departmental Bulletin Paper
  • 雑誌種別
    大学紀要
  • ISSN
    09146385
  • NDL 記事登録ID
    023447830
  • NDL 請求記号
    Z14-1395
  • データ提供元
    NDL  NII-ELS  IR 
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