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- MORI Nozomu
- Department of Anatomy and Neurobiology, Nagasaki University School of Medicine
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- MORI Mari
- Department of Anatomy and Neurobiology, Nagasaki University School of Medicine Department of Biomedical Informatics, University of Pittsburgh School of Medicine
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抄録
Among the countries in the developed world, Japan has the longest mean lifespan for women; however, the nation has encountered serious problems in policy and economics, as well as in managing medical care for its aging population. Aging is inevitable, but it also constitutes a major challenge in modern biology and medicine. In the treatment of geriatric patients, an understanding of the fundamental biological mechanisms of aging and longevity is crucial for the effective treatment and prevention of diseases and disorders, including dementia, osteoporosis, and sarcopenia. To address the most basic questions about aging, including determinants of lifespan and the identity of critical genes and anti-aging factors, we discuss paradoxical phenomena in the biology of longevity, with a particular focus on "time" and "size" of organisms. We also discuss essential factors and/or activities associated with anti-aging mechanisms in connection with brain function in adults and the elderly. Finally, we discuss unique features of the Shc gene family, which is involved in longevity determination, brain size restriction, cognitive functions, and evolution. The aim of this paper is to offer some insight into various problems in gerontology and geriatrics for future research.
収録刊行物
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- Acta Medica Nagasakiensia
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Acta Medica Nagasakiensia 56 (3), 73-80, 2012
長崎大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390282679653498368
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- NII論文ID
- 110008767597
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- NII書誌ID
- AA00508430
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- HANDLE
- 10069/27500
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- ISSN
- 00016055
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可