In vitro evaluation of calcium alginate gels as matrix for iontophoresis electrodes

• Haida Haruka

  Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

• Ando Shizuka

  Saitama Social Welfare Agency Asaka-Kouyouen Dental Clinic for Disability

• Ogami Saori

  Department of Anesthesiology, Fujita Health University School of Medicine

• Wakita Ryo

  Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

• Kohase Hikaru

  Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

• Saito Norio

  Department of Metallurgy and Ceramics Science, Graduate School of Engineering, Tokyo Institute of Technology

• Yoshioka Tomohiko

  Department of Metallurgy and Ceramics Science, Graduate School of Engineering, Tokyo Institute of Technology

• Ikoma Toshiyuki

  Department of Metallurgy and Ceramics Science, Graduate School of Engineering, Tokyo Institute of Technology

• Tanaka Junzo

  Department of Metallurgy and Ceramics Science, Graduate School of Engineering, Tokyo Institute of Technology

• Umino Masahiro

  TTI ellebeau, Inc.,

• Fukayama Haruhisa

  Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

抄録

Calcium alginate gel has some unique properties, such as the capability to keep the drugs, bioadhesiveness, safety, and low cost. The purpose of this study is to determine whether calcium alginate gel can be used as a matrix of electrodes for iontophoresis (IOP). We measured the concentration of lidocaine transported from calcium alginate gels with various concentrations of alginic acid using an in vitro experimental cell with square-wave alternating current (AC) application. Temperature and pH changes were also determined during AC-IOP. The results revealed that lidocaine was released from calcium alginate gels at concentrations nearly 1.71-fold larger at 5 V, 60 min after AC application than in the case of passive diffusion. Lidocaine transport depended on the alginic acid concentration in the gels. Although there were slight increases in temperature and pH, chemical and thermal burns were not severe enough to be a concern. In conclusion, the calcium alginate gel can be used as a possible matrix for IOP electrodes.

収録刊行物

• Journal of medical and dental sciences

  Journal of medical and dental sciences 59 (1), 9-16, 2012-03

  東京医科歯科大学

キーワード

• Drug delivery system (DDS)
• Iontophoresis (IOP)
• Calcium alginate gel
• Alternating Current (AC)
• Electrode

詳細情報

• CRID: 1573387451824966528
• NII論文ID: 110008904364
• NII書誌ID: AA12028964
• ISSN: 21859132
• 本文言語コード: en
• データソース種別:
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