牡丹皮の研究-3-牡丹皮の抗炎症作用-1- Studies on MOUTAN CORTEX (III) : On Anti-inflammatory Activities (Part 1)
In traditional Chinese medicine, "Mudanpi" (Paeonia moutan SIM., root cortex) is one of the most important crude drugs, and is used particularly for the treatment of female genital inflammatory diseases. In this work, the anti-inflammatory effects of 70% MeOH extract of "Mudanpi" and of various fractions derived therefrom were examined. The 70% MeOH extract inhibited the arthritis induced by Freund's complete adjuvant in rat, and the glyco-sidic fraction containing no paeonol which is a major component of "Mudanpi", inhibited blood platelet agglutination, and showed anti-plasminogen and anti-plasmin activities. The fact that "Mudanpi" significantly inhibited autoimmune and/or allergic inflammation is in good accord with the clinical applications of "Mudanpi" practised in traditional Chinese medicine.
生薬学雑誌 33(3), p178-184, 1979-09