Innovation of Human Specific Disease Research Using Humanized Mouse : Complemented Research between Applied Mathematics and Experimental Medicine(<Special Topics>Mathematical Model of Disease)

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  • ヒト化マウスを用いたヒト特異的疾患研究のイノベーション : 応用数学と実験医学の融合(<特集>疾患の数理モデル)
  • ヒト化マウスを用いたヒト特異的疾患研究のイノベーション : 応用数学と実験医学の融合
  • ヒトカ マウス オ モチイタ ヒト トクイテキ シッカン ケンキュウ ノ イノベーション : オウヨウ スウガク ト ジッケン イガク ノ ユウゴウ

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Abstract

Recently, in order to investigate the fundamental phenomena in immunology and virology such as maintenance of immune memory, T-cell homeostasis, the relationship between aging and immunosenescence, the regulation of the adaptive immune response during viral infection, the pathogenesis of CD4^+ depletion in HIV infection, and the underlying mechanisms of leukemia, we successfully quantied lymphocyte kinetics in humanized mice through BrdUlabeling experiment. It is worth noting that our findings are the first to assess lymphocyte dynamics utilizing this technique. At first, we will briefly give an outline of the "Quantification system of lymphocyte kinetics in humanized mice" and then we will discuss about properties of the lymphocyte kinetics and utilities of our established system.

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