就寝前の加温カフェインによる連続洗口は健常者の口腔内細菌叢を変化させる  [in Japanese] Hot Caffeine Solution-Containing Mouthwashes Used Nightly Change Human Oral Microbiota in Healthy Subjects  [in Japanese]

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Abstract

 カフェインは,コーヒー,紅茶,緑茶および烏龍茶などの飲料に含まれる良く知られた成分の一つである.それらの飲料は加温して飲まれることが多い.われわれのこれまでの<i>in vitro</i>での試験において,そのような加温されたカフェイン液(HC)が,短時間で,口腔常在細菌種と比較して多くの誤嚥性肺炎起因菌種の生存率を低下させ,口腔細菌叢を改善する可能性が示された.そこで,HCが実際に口腔細菌叢に影響を及ぼすかどうかを調べるため,健常者を被験者(n=9)として単群のブラインド化されない27日間の介入試験を実施した.この結果,好気性連鎖球菌は,好気性細菌の中で高い割合を示し,介入による変化がみられなかった.嫌気性細菌では,介入により嫌気性連鎖球菌の割合が上昇し,<i>Prevotella</i>属の割合が減少傾向を示し,歯周病菌等嫌気性のグラム陰性菌の割合が減少した可能性が示唆された.これらの結果から,HCによる洗口は,常在菌の割合を留め,歯周病菌等の割合を減少させることにより,健康な健常者の細菌叢を改善したものと推察された.

 Caffeine is one of the most well-known chemical compounds contained in beverages such as coffee, black tea, green tea, and oolong tea. In many cases, these beverages are drunk after being heated. In our previous <i>in vitro</i> studies, it was suggested that such hot caffeine (HC) solutions decrease the survival rate of pathogenic bacterial species causing aspiration pneumonia more significantly than in oral bacterial species, and improve the human oral microbiota in a short period of time. For this reason, we performed a single arm, non-blinded intervention test in healthy subjects (n=9) to reveal the effects of HC on the human oral microbiota for 27 days. As a result, it was shown that the rate of aerobic streptococci was high in the total aerobic bacteria, and that there was no change in the rate of bacteria due to the intervention. Ragarding anaerobic bacteria, the rate of anaerobic streptococci was increased by the intervention, whereas the rate of <i>Prevotella</i> was decreased, suggesting that the rate of anaerobic Gram-negative bacteria, such as periodontal pathogens, might have been decreased. These results suggest that washing the mouth with HC might improve the human oral microbiota in healthy subjects by decreasing the rate of periodontal pathogens, while maintaining the rate of oral bacterial species.

Journal

  • JOURNAL OF DENTAL HEALTH

    JOURNAL OF DENTAL HEALTH 62(4), 357-364, 2012

    Japanese Society for Oral Health

References:  30

Codes

  • NII Article ID (NAID)
    110009489298
  • NII NACSIS-CAT ID (NCID)
    AN00081407
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    0023-2831
  • NDL Article ID
    023925078
  • NDL Call No.
    Z19-144
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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