Oral Conditions that Affect Salivary Biomarkers : Preliminary Survey by Self-administrated Questionnaire

• KAKUTA Erika

  Department of Translational Research, School of Dental Medicine, Tsurumi University

• Ida Akira

  Department of Translational Research, School of Dental Medicine, Tsurumi University:Ida Dental East Clinic

• NOMURA Hiromi

  Ida Dental East Clinic

• TAMAKI Yoh

  National Institute of Public Health

• ABO Tomoko

  Department of Translational Research, School of Dental Medicine, Tsurumi University

• OTSUKA Ryoko

  Department of Operative Dentistry, School of Dental Medicine, Tsurumi University

• MURATA Takatoshi

  Department of Translational Research, School of Dental Medicine, Tsurumi University

• NOMURA Yoshiaki

  Department of Translational Research, School of Dental Medicine, Tsurumi University

• HANADA Nobuhiro

  Department of Translational Research, School of Dental Medicine, Tsurumi University

Bibliographic Information

Other Title

• 唾液マーカーと口腔内自覚症状との関係 : 歯周病スクリーニングにおける予備的研究

Abstract

 Recently, salivary biomarkers such as lactose dehydrogenase (LD) and hemoglobin (Hb) have been used to screen for periodontal disease without oral examination by dental professions. These salivary biomarkers reflect bleeding from the oral cavity. Self-reported questionnaires are often used for mass screening for periodontal disease. The items on such questionnaires generally apply to lifestyle and subjective symptoms; however, not all of the data from questions are necessary to screen for periodontal disease. This study aimed to identify indispensable items on the questionnaire, and investigated the relationship between such symptoms and salivary biomarkers. <br> The 46 subjects attended a health check in Higashi Oumi City. We excluded 3 subjects: 1 subject because of an incomplete questionnaire and 2 subjects because they were outliers with regard to salivary biomarkers. Thus, the number of subjects studied was 43 (male, 3; female, 40; mean age, 51.8 ± 9.8 year). The questionnaire used in this study consisted of 8 items related to subjective oral symptoms and lifestyle factors such as smoking status. Salivary levels of LD and Hb were measured using commercially available kits that were developed for routine medical examination. We compared the values of salivary biomarkers between subjects with or without each symptom. In addition, to classify the subjects participating in this study, two-step cluster analysis was performed. <br> The values for Hb were clearly higher in subjects reporting "Gum bleeding or flowing pus" and "Dry mouth sensation". The values for LD and Hb were higher in subjects with 7 symptoms (not statistically significant). <br> Periodontal disease is not the only cause of bleeding from the oral cavity; the oral mucosa is sensitive to dryness, and this may lead to high values of Hb in subjects with dry mouth sensation. <br> These results suggest that salivary biomarkers such as Hb are useful to screen for periodontal disease and dry mouth; however, this was a preliminary survey, and further research is necessary in larger numbers of subjects.

Journal

• JOURNAL OF DENTAL HEALTH

  JOURNAL OF DENTAL HEALTH 62 (4), 391-396, 2012

  Japanese Society for Oral Health

Keywords

• Salivary test
• Hemoglobin
• Lactose dehydrogenase
• Questionnaire
• Periodontal disease

Details

• CRID: 1390001205002639360
• NII Article ID: 110009489302
• NII Book ID: AN00081407
• DOI: 10.5834/jdh.62.4_391
• ISSN: 21897379
• ISSN: 00232831
• NDL BIB ID: 023925163
• Web Site: http://id.ndl.go.jp/bib/023925163
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023925163
• Web Site: https://search.jamas.or.jp/link/ui/2012333654
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed